慢性肝炎血浆内毒素水平与中医虚实证及肝脏病理分级分期的关系

Relationship of Plasma Endotoxin Level with TCM Deficiency/Excess Syndrome and Grading/Staging of Pathologic Change of Liver in Patients with Chronic Hepatitis

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DOI：

中文关键词: 慢性病毒性肝炎中医分型内毒素

英文关键词:chronic viral hepatitis TCM Syndrome typing endotoxin

基金项目:

作者	单位
陈云	南京军区福州总医院
杜建	福建中医学院
王玉海	福州市传染病医院

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中文摘要:

目的探讨慢性乙型肝炎血浆内毒素水平与中医虚实证及肝脏病理损害的关系。方法对 75例慢性乙型肝炎患者 (其中偏实证组 30例 ,偏虚证组 4 5例 )采用基质显色法检测血浆内毒素 (endotoxin ,ET)水平 ,以同期健康体检正常者 15名作对照。并对其中 2 0例患者行肝组织活检。结果 (1)慢性乙型肝炎患者血浆ET水平偏实证组较偏虚证组升高明显 ,二者比较差异有显著性 (P <0 0 1)。 (2 )慢性乙型肝炎患者血浆ET水平与肝脏病理分级分期存在相关性。结论血浆ET水平可作为慢性乙型肝炎中医虚、实辨证微观辨证参考指标之一。内毒素血症 (endotoxemia ,ETM )在肝脏病理损害过程中起重要作用

英文摘要:

Objective To explore the relationship of plasma endotoxin level with TCM deficiency/excess Syndrome and the grading/staging of pathologic change of liver in patients with chronic hepatitis B (CHB). Methods Plasma level of endotoxin (ET) was determined using chromogenic limulus amebocyte lysate (LAL) assay in 75 patients with chronic hepatitis B (30 of excess dominance, 45 of deficiency dominance) and also in 15 healthy subjects for control. Moreover, pathological examination on liver biopsy of 20 patients was conducted. Results (1) ET level increased in all CHB patients, and the increment was higher in patients of excess dominance than that in patients of deficiency dominance, showing significant difference (P<0 01). (2) Correlation between ET level and liver pathological grading/staging was shown in CHB patients. Conclusion Plasma level of ET could be taken as one of the criteria of TCM microcosmic diagnosis in differentiating deficiency/excess syndrome. (2) Endotoxemia plays an important role in pathologic process of liver injury.

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