充血性心力衰竭心气虚、心阳虚证与肿瘤坏死因子-α及白细胞介素关系的研究

Study on Relationship between TCM Syndrome Types (Xin Qi and Xin Yang Deficiency) and Contents of Cytokines (Tumor Necrosis Factor α and Interleukins) in Patients with Congestive Heart Failure

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DOI：

中文关键词: 心力衰竭肿瘤坏死因子α 白细胞介素6 白细胞介素1β 白细胞介素10 心气虚心阳虚

英文关键词:heart failure tumor necrosis factor α interleukin 6 interleukin 1β interleukin 10 Xin qi deficiency Xin yang deficiency

基金项目:

作者	单位
陈瑞	华中科技大学同济医学院附属协和医院
梁凤霞	湖北中医学院
黄艳霞	华中科技大学同济医学院附属协和医院
李彬	华中科技大学同济医学院附属协和医院

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中文摘要:

目的探讨充血性心力衰竭 (CHF)患者心气虚、心阳虚证与肿瘤坏死因子 α(TNF α)、白细胞介素 6(IL 6)、白细胞介素 1 β(IL 1 β)及白细胞介素 1 0 (IL 1 0 )的关系。方法选取CHF心气虚、心阳虚证住院患者 67例 ,分别进行NYHA心功能分级 ,并采用心脏多普勒仪测定射血分数 (EF)、E峰 /A峰 (E/A)比值 ,采用双抗体夹心ELISA法检测血清TNF α、IL 6、IL 1 β及IL 1 0。结果心气虚证组患者心功能分级以舒张功能不全、心功能Ⅰ级、Ⅱ级为多 ,心阳虚证组患者以Ⅲ级、Ⅳ级为多 (Ridit分析 ,P <0 0 1 ) ;心气虚证组患者E/A值、EF值高于心阳虚证组患者 (P <0 0 1 ) ;心阳虚证组患者血清TNF α、IL 6、IL 1 β水平高于心气虚证组患者 (P <0 0 1 ,P <0 0 5 ) ;心阳虚证组患者血清IL 1 0水平低于心气虚证组患者 (P <0 0 1 )。结论TNF α、IL 6、IL 1 β与IL 1 0可能在CHF心气虚证向心阳虚证发展过程中起重要的作用 ,可能成为心气虚证、心阳虚证微观辨证的指标。

英文摘要:

Objective To explore the relationship between TCM Syndromes types, Xin qi deficiency (XQD) and Xin yang deficiency (XYD), and contents of cytokines, including tumor necrosis factor α (TNF α), interleukin 6 (IL 6), IL 1β and IL 10 in patients with congestive heart failure (CHF). Methods Sixty seven CHF in patients with Xin qi deficiency or Xin yang deficiency syndrome were enrolled, their NYHA (New York Heart Association) cardiac function was assessed, ejection fraction (EF) and E peak/A peak (E/A) ratio were determined by Doppler ultrasonic echocardiograph, and serum TNF α, IL 6, IL 1β and IL 10 were measured by double antibody sandwich ELISA assay. Results The cardiac function grading in patients of XQD was mostly of Ⅰ and Ⅱ grade, while that in patients of XYD was mostly of Ⅲ and Ⅳ grade (by Ridit analysis, P<0.01). The E/A and EF values were higher in patients of XQD than those in patients of XYD (P<0.01). Levels of TNF α, IL 6 and IL 1β were higher and IL 10 was lower in patients of XYD than those in patients of XQD (P<0 05 or P<0 01) respectively. Conclusion TNF α, IL 6, IL 1β and IL 10 probably play an important role in the development process of XQD to XYD, and could be taken as the microcosmic indexes for differentiation of the two syndromes.

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