复方丹参注射液对外伤性脑梗死患者凝血功能的影响

作者	单位
张荣军	四川大学华西医院神经外科成都610041
游潮	四川大学华西医院神经外科成都610041
蔡博文	四川大学华西医院神经外科成都610041
苑玉清	四川大学华西医院神经外科成都610041
贺民	四川大学华西医院神经外科成都610041
李浩	四川大学华西医院神经外科成都610041

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中文摘要:

目的研究复方丹参注射液对外伤性脑梗死患者凝血功能的影响。方法将 64例外伤性脑梗死患者随机分为治疗组和对照组 ,每组 32例。治疗组给予复方丹参注射液加西药常规治疗 ,对照组仅西药常规治疗 ;观察用药前后患者症状改善程度及血浆P 选择素 (P selectin)、血管性血友病因子 (vWf)和D 二聚体 (D dimer)水平的变化。结果两组格拉斯格恢复评分 (GlasgowOutcomeScale,GOS) ,治疗组优于对照组 (P <0 0 1 )。外伤性脑梗死患者血浆P selectin、vWf和D dimer治疗前明显高于健康人 ,治疗后两组患者P selectin、vWf和D dimer水平均下降 ,治疗组优于对照组。结论外伤性脑梗死患者体内存在着凝血功能障碍 ,复方丹参注射液可改善外伤性脑梗死患者的凝血功能 ,可能在一定程度上减轻外伤性脑梗死患者的脑损害。

英文摘要:

Objective To investigate the effect of compound Salvia injection (CSI) on blood coagulatory function in patients with traumatic cerebral infarction (TCI). Methods Sixty four patients with TCI were randomly divided into two groups, 32 in each group. The treated group were treated with CSI plus conventional treatment of western medicine, and the control group treated with conventional treatment alone. Changes of symptoms, levels of plasma P selectin (P S), von Willebrand’s factor (vWf) and D dimer were observed with ELISA. ResultsThe treated group was superior to the control group in Glasgow outcome scale (P<0 01). Before treatment, the levels of plasma P S, vWf and D dimer in the TCI patients were higher than those in healthy people. After treatment, all the parameters lowered in both groups, but the effect of lowering was greater in the treated group than that in the control group. Conclusion Blood coagulation disorder exists in patients with TCI, CSI could improve it, and might alleviate the cerebral damage to a certain extent.

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