参芪扶正注射液辅助化疗治疗老年非小细胞肺癌临床观察

作者	单位
刘城林	广州医学院临床肿瘤研究中心广州市肿瘤医院
陈为平	广州医学院临床肿瘤研究中心广州市肿瘤医院
崔书中	广州医学院临床肿瘤研究中心广州市肿瘤医院
邓广业	广西壮族自治区民族医院
刘丽萍	广东省肇庆市第一人民医院
覃丽红	广东省肇庆市第一人民医院
苏旭春	广州医学院临床肿瘤研究中心广州市肿瘤医院
闫冰川	广州医学院临床肿瘤研究中心广州市肿瘤医院
孔嘉欣	广州医学院临床肿瘤研究中心广州市肿瘤医院

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中文摘要:

目的观察参芪扶正注射液对老年非小细胞肺癌 (NSCLC)化疗的影响。方法 1 2 0例老年NSCLC患者均采用NP方案化疗 ,其中治疗组 60例化疗前 1周开始加用参芪扶正注射液。观察两组近期疗效、远期生存率、化疗后生活质量评价、血液毒性反应及免疫功能变化情况。结果两组近期疗效及 1、2年生存率比较差异无显著性 (P >0 .0 5 ) ,但 3年生存率治疗组为 4 5 7%,对照组为 1 9 4 %,前者高于后者(P <0 0 5 ) ;化疗后患者生活质量评价治疗组优于对照组 (P <0 .0 5 )。此外 ,治疗组化疗后血液毒性反应、明显低于对照组 ,差异有显著性 (P <0 .0 5 ) ;免疫功能与治疗前比较差异无显著性 (P >0 0 5 )。结论参芪扶正注射液对老年NSCLC化疗有一定减毒作用。

英文摘要:

ObjectiveTo study the effect of chemotherapy assisted with Shenqi Fuzheng Injection (SFI) on senile patients with non small cell lung cancer (NSCLC). MethodsOne hundred and twenty old patients with NSCLC were treated with NP chemotherapeutic protocol, to the 60 patients in the treated group among them, additional medication of SFI was started one week before the beginning of chemotherapy. The short term therapeutic efficacy, long term survival rate, changes on quality of life (QOL) and immune function of patients, and hematological toxicity of therapy were observed. ResultsDifference between the two groups on short term therapeutic effect, 1 and 2 year survival rate showed no significance (P>0.05), but the 3 year survival rate in the treated group was 26 6%, while that in the control group was 11 7%, showed that the former was higher than the latter. After treatment QOL of the treated group was better than that of the control (P<0.05). Besides, the hematological toxicity and affection on immune function of chemotherapy after treatment in the treated group were all lower than those in the control group showing significant difference (P<0.05).ConclusionSFI has definite toxicity relieving effect on chemotherapy in treating senile NSCLC.

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