麝香保心丸对2型糖尿病合并心绞痛患者血管内皮功能的影响

Effect of Shexiang Baoxin Pill on the Function of Vascular Endothelium in Patien ts with Diabetes Mellitus Type 2 Complicated with Angina Pectoris

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DOI：

中文关键词: 2型糖尿病心绞痛麝香保心丸缓释单硝酸异山梨酯内皮功能

英文关键词:diabetes mellitus type 2 an gina pectoris Shexiang Baoxin pill delayed-released isosorbide mononitrate e ndothelial function

基金项目:

作者	单位
毛玉山	复旦大学华山医院内分泌科
李福军	浙江省宁波市镇海炼化医院
周丽诺	宁波大学医学院附属医院
叶红英	宁波大学医学院附属医院
杜娟	浙江省宁波市镇海炼化医院
申定国	浙江省宁波市镇海炼化医院
施淑钧	浙江省宁波市镇海炼化医院
黄童	浙江省宁波市镇海炼化医院
洪中立	浙江省宁波市镇海炼化医院

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中文摘要:

目的探讨麝香保心丸 (SBP)对 2型糖尿病合并心绞痛患者血管内皮功能的影响。方法 111例 2型糖尿病合并心绞痛患者 ,经 2周导入期后 ,按随机数字表分为麝香保心丸 (SBP)组 5 6例 ,缓释单硝酸异山梨酯 (DRIM )组 5 5例 ,治疗期 6个月。治疗期间以日记卡形式记录心绞痛的发作次数和硝酸甘油的应用情况 ,观察两组治疗前后肱动脉超声检测血管内皮功能的变化。结果两组心绞痛发作次数和硝酸甘油应用差异无显著性。DRIM组治疗前后肱动脉内径基础值分别为 (3 6 8± 0 5 6 )mm和 (3 70± 0 5 8)mm、反应性充血前后内径分别为 (5 4 4± 0 81) %和 (5 6 8± 0 83) %及含服硝酸甘油前后内径分别为 (19 8±4 9) %和 (2 0 1± 5 2 ) % ,差异均无显著性 (均P >0 0 5 )。SBP组治疗前后肱动脉内径基础值分别为 (3 73± 0 6 2 )mm和 (3 71± 0 5 9)mm、含服硝酸甘油前后内径分别为 (18 8± 4 5 ) %和 (19 2± 5 8) % ,差异也均无显著性 (均P >0 0 5 ) ;但反应性充血前后肱动脉内径分别为 (5 6 9± 0 79) %和 (9 5 6± 3 82 ) % ,差异有显著性 (P <0 0 1)。结论麝香保心丸能改善 2型糖尿病合并心绞痛患者的血管内皮功能。

英文摘要:

ObjectiveTo study the effect of Shexiang Baoxi n pill (SBP) on the va scular endothelial function in patients with diabetes mellitus type 2 (DM2) comp licated with angina pectoris. MethodsTwo weeks after ru n-in, according to the randomizing table, 111 patients were divided into two groups, the XBP group (5 6 patients) and the control group (55 patients, treated with delayed-r eleased isosorbide mononit rate, DRIM), they were treated for 6 months. In the treatment period, the episod es of angina attack and condition of rescue medication were recorded in the dail y card, and brachial arterial changes of endothelium-dependent relaxing functio n before and after treatment were measured by B-ultrasonography. ResultsC omparison between the two groups in episodes of angina attack and rescue medication were insignificantly different. In the control group, the basal value of brachial arterial inner di ameter before and after treatment was 3.68±0.56 mm and 3.70±0.58 mm respec tive ly, those before and after responsive congestion was 5.44±0.81% vs 5.68±0. 83%, and those before and after taking nitroglycerin was 19.8± 4.9% vs 20.1±5. 2%, all showed insignificant difference (P>0.05). In the SBP group , the correspondin g basal value was 3.73± 0.62 mm vs 3.71± 0.59 mm, and those after taking n itro glycerin 18.8± 4.5% vs 19.2±5.8%, also showed insignificant difference, bu t th ose before and after responsive congestion (5.69±0.79% vs 9.56±3.82%) did show significant difference (P<0.01). ConclusionXBP could improve the vascular en dothelial function in patients with DM2 complicated with angina pectoris.

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