针刺曲池、太冲对高血压病患者血中ET和ACE的影响及疗效探讨

作者	单位
吴远华	贵阳中医学院第二附属医院
朱广旗	贵阳中医学院第二附属医院
林兴友	贵阳中医学院
欧阳冷星	贵阳中医学院
苏红梅	贵阳中医学院
吴邦启	贵阳中医学院

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中文摘要:

目的观察针刺曲池、太冲穴对高血压病患者血中血管紧张素转化酶 (ACE)和内皮素 (ET)含量的影响 ,探讨曲池、太冲穴针刺降压的作用机制。方法将 6 0例高血压病患者随机分为太冲组、曲池组与药物对照组。太冲组与曲池组应用针刺治疗 ,药物对照组口服卡托普利 ,3组均治疗 1个疗程 (5天 )。并应用放免法测定血浆ET含量和化学比色法测定血清ACE含量。结果针刺后 15min和取针后 12 0min ,曲池组对收缩压 (SBP)的疗效优于太冲组 (P <0 0 1,P <0 0 5 ) ,而在 1个疗程后 ,曲池组和药物对照组疗效明显优于太冲组 (P <0 0 5 ,P <0 0 1)。曲池组能增加高血压病患者血清中ACE的含量 ,与太冲组比较差异有显著性 (P <0 0 1)。而太冲组能降低血浆中ET的含量 ,与曲池组比较差异亦有显著性 (P <0 0 1)。结论针刺曲池、太冲穴均有降压疗效 ,但曲池穴明显优于太冲穴。针刺曲池、太冲能调节ACE和ET的含量 ,保护和修复血管内皮细胞 (VEC) ,但两者降压机制的主要作用环节可能不同。

英文摘要:

<AbstractObjectiveTo observe the effect and explore the mechanism of needling Quchi and Taichong points in treating hypertension patients and the influence on blood levels of angioten sion converting enzyme (ACE) and endothelin (ET) levels. MethodsSixty hypertension patients we re randomly divided in to the Taichong needling group (A), Quchi needling group (B) and control group ( C, treated by Captopril). Changes of plasma ET was determined by radioimmunoassa y (RIA) and serum ACE content was measured by chemical colorimeter. Res ultsThe effect of lowering systolic pressure at 15 min after needling in Group B was be tter than that in Group A (P<0.01), but it was inferior to the latter at 120 min after withdrawal of needle (P<0.05), while after one course t reatment, the effe ct in Group B and C was obviously better than that in Group A (P<0.05 and P<0.01 ).Content of serum ACE significantly increased in Group B and that of plasma ET significantly decreased in Group A, showing significant difference between the t wo groups, all P<0.01. ConclusionNeedling Quchi and Taichong all show hypertens ive effect, the former is obviously higher than that of the latter. They could r egulate the blood level of ACE and ET, protect and repair vascular endothelial c ells, but the key links of their mechanism might be different.

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