| 孙云,徐峰,张洪泉.阿魏酸钠拮抗豚鼠哮喘的药理机制研究[J].中国中西医结合杂志,2004,(12):1103-1105 |
| 阿魏酸钠拮抗豚鼠哮喘的药理机制研究 |
| Study on the Pharmacological Mechanism of Sodium Ferulate for Anti-ast hmatic Eff ect in Guinea Pigs |
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| DOI： |
| 中文关键词: 阿魏酸钠 哮喘 内皮素 一氧化氮 嗜酸性粒细胞 |
| 英文关键词:sodium ferulate asthma end othelin nitric oxide eosinophil |
| 基金项目:江苏省科学委员会基金项目 (No .BK981 3531 3) |
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| 中文摘要: |
| 目的研究阿魏酸钠对豚鼠哮喘的作用及其机制。方法致敏豚鼠给予 2 5、5 0、10 0mg/kg 3种不同浓度的阿魏酸钠 ,并用卵白蛋白引喘豚鼠 ,检测引喘后 8天豚鼠血清与肺组织中的内皮素 1(ET)、一氧化氮 (NO)以及血液、肺泡灌洗液 (BALF)中嗜酸性粒细胞 (EOS)的变化情况。结果阿魏酸钠可明显降低血清和肺组织中的ET含量 (P <0 0 5 ,P <0 0 1) ,升高血清和肺组织中NO浓度 (P <0 0 5 ,P <0 0 1) ,减少血液和肺泡灌洗液中EOS的数量 (P <0 0 5 ,P <0 0 1) ;高剂量组作用较强。结论阿魏酸钠可增加体内NO浓度 ,降低ET含量、减轻EOS浸润 ,拮抗豚鼠哮喘。 |
| 英文摘要: |
| ObjectiveTo study the anti-asthmatic effect o f sodium ferulate (SF) and its mechanism in guinea pig asthmatic model. MethodsGuinea pigs were sens itized with ovalbumin as animal asthmatic model and treated with 3 different con centration of SF for 8 days. Levels of endothelin (ET) and nitric oxide (NO) in blood and lung tissue, and eo sinophil (EOS) in blood and bronchoalveolar lavage fluid (BLAF) was counted at t he end of trial. ResultsSF could significantly lower th e ET content and incre ase the NO concentration in serum and lung tissue, reduce the number of EOS in b lood and BLAF (P<0.05, P<0.01). Stronger eff ect was showed in the high dose group. ConclusionMechanism of anti-asthmatic action of SF might be to increase NO concent ration, lower ET content, alleviate EOS infiltration. |
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