消瘤汤治疗肿瘤及调节免疫功能的实验研究

目的探讨消瘤汤抗肿瘤的作用及调节免疫功能的机理。方法用大、小剂量消瘤汤及环磷酰胺 (CTX)治疗荷瘤 (S180 )小鼠 ,观察其抑瘤率、淋巴细胞转化率、并测定自然杀伤 (NK)细胞活性、肿瘤坏死因子 (TNFα)含量及体外肿瘤细胞的凋亡。结果消瘤汤对荷瘤小鼠的抑瘤率大于 30 % ,而且与化疗药合用有明显增强化疗抑瘤率的趋势 ;提高荷瘤小鼠淋巴细胞转化率、NK细胞活性、TNFα含量 ,对体外肿瘤细胞的凋亡有加速作用。结论消瘤汤具有明显的抗肿瘤作用 ,能提高机体免疫功能 ,并可以拮抗化疗造成的免疫功能下降。

英文摘要:

ObjectiveTo study the anti-tumor effect and i mmune function modulati on of Xiaoliu decoction (XLD) and to explore the possible mechanism. Me thodsS 180 tumor bearing mice were treated with large or small dose of XLD and cyclopho sphamide (CTX) to observe the tumor suppressive rate, lymphocyte transformation rate, natural killer cell (NK) activity, tumor necrosis factor α (TNFα) leve l in the mice, as well as the tumor cell apoptosis in vitro. Res ultsThe tumor suppressive rate of XLD on tumor bearing mice was over 30%. XLD showed obvious t rend in enhancing the tumor suppressing rate of chemotherapy, could increase the lymphocyte transformation rate, NK activity, and TNFα level. It also could a cc elerate the tumor cell apoptosis in vitro. ConclusionXLD has significant anti-tu mor effect, it could elevate the immune function or organism and alleviate the c hemotherapy induced lowering of immune function.

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