| 王书臣,张燕萍,樊茂蓉,苗青,王伟,张文江,张元元,林家扬.肺纤平对肺纤维化大鼠血清白细胞介素6及动脉血氧分压的影响[J].中国中西医结合杂志,2005,(2):147-149 |
| 肺纤平对肺纤维化大鼠血清白细胞介素6及动脉血氧分压的影响 |
| Effects of Feixianping on Serum Interleukin-6 and Oxygen Partial Pressure in Pulmonary Fibrosis Rats |
| 免费下载全文 查看/发表评论 下载PDF阅读器 |
| |
| DOI： |
| 中文关键词: 肺纤维化 肺纤平 IL-6 动脉血氧分压 |
| 英文关键词:pulmonary fibrosis Feixianping interleukin-6 arterial partial pressure oi oxygen |
| 基金项目:国家自然科学基金资助项目(No30340076)国家中医药管理局基金资助项目(No.2000-J-B-21) |
|
| 摘要点击次数: 1251 |
| 全文下载次数: 1365 |
| 中文摘要: |
| 目的 探索肺纤平对实验性肺纤维化大鼠低氧血症的改善情况,以及对血清白细胞介素6(IL-6)的影响。方法 240只健康SD雄性大鼠随机分为5组,即正常对照组、肺纤维化模型组、泼尼松组和肺纤平低、高剂量组,除正常对照组外,其余4组均复制肺纤维化模型,各组于造模后第1天给药,分别在第7、14、21、28天将疗程结束的动物处死,取动脉血测动脉血氧分压(PaO2),并检测血清IL-6的含量。结果 各个时间段肺纤维化模型组大鼠血清IL-6含量始终高于正常对照组及各治疗组(P<0.01),第7、14和28天时肺纤平组大鼠血清IL-6含量分别与泼尼松组和正常对照组比较差异无显著性;在实验第14天后肺纤平即可改善大鼠实验性低氧血症,其改善情况与泼尼松基本一致。结论 肺纤平可改善肺纤维化大鼠实验性低氧血症,并可以抑制IL-6的异常增高。 |
| 英文摘要: |
| To study the effects of Feixianping (FXP) in improving hypoxemia and on serum interleukin-6 (IL-6) in experimental rats with pulmonary fibrosis (PF). Methods Two hundred and forty healthy male SD rats were randomly divided into 5 groups, 48 in each group, i.e. the normal control group (A), the model group (B), the prednisone group (C) and the two FXP groups of high (21.6 mg·kg-1) and low (10.8 mg·kg-1) dosage (D and E). PF model rats were established by intratracheal instillation of bleomycin, excepting those in Group A, to which normal saline was administered. The corresponding treatment to various groups started from the 1st day after modeling. Rats were sacrificed in batch at 4 time points, i. e. , the 7th, 14th, 21st and 28th day, their arterial blood was collected for determination of blood partial pressure of oxygen (PaO2) and serum IL-6 content. Results Serum IL-6 content in Group B at all the time points was higher than that in other groups at the same time points (P<0.01). In the FXP treated groups (D and E), levels of IL-6 at the 7th, 14th and 28th day showed no significant difference from those in Group A and C. Since the 14th day, FXP showed its effect in improving hypoxemia in experimental rats which could basically keep in accordance with the effect of prednisone. Conclusion FXP can ameliorate hypoxemia and reduce the level of serum IL-6 in experimental PF rats. |
| 关闭 |
|
|
|
扫描微信二维码，获取更多信息