精制血府胶囊对颈动脉粥样硬化患者颈动脉超声相关指标的影响

作者	单位
董国菊	中国中医研究院西苑医院心血管科北京100091
刘剑刚	中国中医研究院西苑医院心血管科北京100091
史大卓	中国中医研究院西苑医院心血管科北京100091

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中文摘要:

目的观察精制血府胶囊对45例颈动脉粥样硬化(carotidatherosclerosis,CAS)患者颈动脉超声的影响。方法将92例CAS患者随机分为两组,治疗组45例在西医常规治疗的基础上给予精制血府胶囊,对照组47例仅给予西医常规治疗,1个月为1个疗程,连续3个疗程。治疗前后均做颈动脉超声进行对比。结果服用精制血府胶囊3个月后,治疗组血管内膜厚度(IMT)、平均斑块数目、斑块积分、最大软斑块或混合斑块的体积指数和长度以及血管面积狭窄率均减少,颈动脉血流阻力指数降低,治疗后与治疗前及对照组治疗后比较,差异均有显著性(P <0 .0 1)。结论精制血府胶囊可以在一定程度上消减血管内膜斑块,改善血流动力学,有一定的防治CAS的作用。

英文摘要:

ObjectiveTo investigate the effect of Purified Xuefu Capsule (PXC) on ultrasonographic figures in patients with carotid atherosclerosis (CAS). MethodsNinety-two patients with CAS were randomly divided into two groups, the 45 patients in the treated group were treated by conventional western medicine with additional PXC, the 47 patients in the control group were given conventional western medicine alone. One month’s treatment was regarded as one course, and three courses of treatment were given successively to both groups.Carotid ultrasonography was performed before and after treatment, and the figures were compared. ResultsThe thickness of endangium, average number of plaques, plaque scores, plaque volume index and length of the biggest soft plaque or mixed plaques, stenosis rate of vascular area, and the resistant index of blood vessels were decreased after treated with PXC for 3 months in the treated group. The differences of these indexes in the treated group before and after treatment, and that between the treated group and the control group after treatment were significant (P<0.01). ConclusionPXC can improve hemodynamics and eliminate atherosclerotic plaque to a certain degree, so it has definite effect for prevention and treatment of CAS.

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