复方杜仲健骨颗粒治疗膝关节骨性关节炎400例临床观察

作者	单位
王和鸣	建省中医药研究院
葛继荣	建省中医药研究院
殷海波	中国中医研究院广安门医院
冯兴华	中国中医研究院广安门医院
朱立国	中国中医研究院骨伤科研究所
张军	中国中医研究院骨伤科研究所
郭振江	北京中医医院
罗涛	北京中医医院

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中文摘要:

目的观察复方杜仲健骨颗粒(bonestrong,伯司庄)治疗膝关节骨性关节炎(肝肾不足、筋脉瘀滞证)的临床疗效和不良反应。方法采用随机对照方法,将复方杜仲健骨颗粒(伯司庄组)400例与壮骨关节丸(对照组)200例进行比较研究。结果(1)伯司庄组临床总有效率为92%,控显率为47%,伯司庄疗效明显优于壮骨关节丸。(2)改善中医证候方面,伯司庄组优于对照组。(3)伯司庄组比对照组起效时间明显加快。(4)伯司庄对病情轻的患者疗效较好。结论复方杜仲健骨颗粒是一种治疗膝关节骨性关节炎安全有效的药物。

英文摘要:

ObjectiveTo study the clinical efficacy and adverse reaction of compound Duzhong Jiangu granule (CDJG) on knee joint osteoarthritis (KJO) of Gan-Shen deficiency with stasis in tendon and muscle syndrome. MethodsThe randomized controlled method was adopted in this study, comparative study was conducted in 400 patients in the treated group treated with CDJG and 200 patients in the control group treated with Zhuanggu Guanjie pill (ZGP). ResultsThe total effective rate in the treated group was 92% and the curative-markedly effective rate was 47%, which were higher than those in the control group respectively.Moreover, CDJG showed superiority in improving symptoms and with shorter initiating time of action as compared with ZGP. However CDJG had the effect more favourable for patients of mild condition. ConclusionCDJG is a kind of effective and safe medicine for treatment of KJO.

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