| 刘运芳,赵玉霞,于会明,孟晓慧,郑玉兰,黄涛.祛瘀消斑胶囊消退动脉粥样硬化的临床研究[J].中国中西医结合杂志,2005,(6):499-501 |
| 祛瘀消斑胶囊消退动脉粥样硬化的临床研究 |
| Clinical Study on Effect of Quyu Xiaoban Capsule on Regression of Atherosclerosis |
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| DOI： |
| 中文关键词: 祛瘀消斑胶囊 动脉粥样硬化 声学密度 |
| 英文关键词:Quyu Xiaoban capsule atherosclerosis acoustic densitometry |
| 基金项目:山东省卫生厅“九五”重点攻关项目(No.9711) |
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| 摘要点击次数: 1599 |
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| 中文摘要: |
| 目的应用高频超声技术观察祛瘀消斑胶囊对动脉粥样硬化(AS)斑块的消退和稳定作用。方法80例AS患者按完全随机设计分为治疗组和对照组,对照组采用常规西药治疗,治疗组采用常规西药加祛瘀消斑胶囊治疗;治疗前两组超声检测动脉内膜-中层厚度(IMT)和图像平均回声强度的校正值(AI-Ic%),并测定其血脂水平,6个月后复查。结果治疗后治疗组TC及LDL-C较治疗前显著降低(P<0.05);治疗组脂质型斑块AIIc%为68.12±5.54,较治疗前61.43±5.37显著增大,且AIIc%变化率〔(10.9±5.1)%〕与对照组〔(2.5±5.5)%〕比较,差异有显著性(P<0.05)。结论祛瘀消斑胶囊能显著降低血脂水平,延缓AS斑块的进展,增加斑块的稳定性。 |
| 英文摘要: |
| ObjectiveTo study the effect of Quyu Xiaoban capsule (QXC) on regression and stabilization of atherosclerotic plaque with high-frequency ultrasound technique. MethodsEighty patients with atherosclerosis (AS) were randomly divided into the treated group and the control group, level of blood lipids was measured, and intima-media thickness (IMT) and corrected value of image average echo intensity (AIIc%) were determined by ultrasound technique at the beginning of experiment and after being treated for six months. ResultsThe levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were significantly decreased in the treated group after treatment (68.12±5.54 vs 61.43±5.37,P<0.05). The AIIc% of fatty atherosclerotic plaque was significantly increased after treatment (68.12±5.54 vs 61.43±5.37), and the change rate of AIIc% in the treated group was significantly different to that in the control group (10.9±5.1% vs 2.5±5.5%, P<0.05). ConclusionQXC can significantly lower the blood lipids level, delay the progress and enhance the stability of atherosclerotic plaque. |
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