| 王亚利,刘薇,姜萍,李可亮,张永峰.葛根素对小儿重症肺炎心肌保护作用的研究[J].中国中西医结合杂志,2005,(6):502-504 |
| 葛根素对小儿重症肺炎心肌保护作用的研究 |
| Myocardial Protective Effect of Puerarin Injection in Children with Severe Pneumonia |
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| DOI： |
| 中文关键词: 葛根素 小儿肺炎 缺氧 心肌损伤 心肌保护 心力衰竭 |
| 英文关键词:puerarin children pneumonia hypoxia myocardial damage myocardial protection heart failure |
| 基金项目:山东省卫生厅立项课题(No.2001CA1CCB7) |
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| 中文摘要: |
| 目的探讨葛根素对小儿重症肺炎心肌保护作用。方法选择婴幼儿肺炎100例,根据病情分为重症组52例、轻症组48例,治疗前后测心肌酶谱、心电图及心脏血流参数。重症组在常规治疗基础上分别进行了葛根素和二磷酸果糖(FDP)心肌保护治疗的比较观察。结果肺炎患儿心肌酶的改变,与病情程度成正比;超声多普勒检查反映心脏血流参数的改变,证明心脏收缩功能下降(P<0.01)。葛根素和FDP均具有保护心肌损伤、改善心功能的作用,两者比较差异无显著性(P>0.05),而葛根素注射液较FDP血管刺激性小,未见明显不良反应发生。结论(1)小儿重症肺炎可以导致心肌损伤和心力衰竭,早期心肌保护治疗能明显改善预后;(2)心肌酶学检查是心肌损伤敏感而重要的测定指标,其中肌酸激酶同功酶(CK-MB)最敏感。(3)葛根素注射液具有保护心肌、改善心功能的作用,适宜临床推广应用。 |
| 英文摘要: |
| ObjectiveTo investigate the myocardial protective effect of puerarin injection (PI) in children with severe pneumonia. MethodsOne hundred children with pneumonia enrolled were divided into two groups according to their condition of illness. Forty-eight children of mild condition in the common group (CG) were treated with conventional treatment and 52 children of serious condition in the severe group (SG) were treated with conventional treatment with additional PI or fructose-1,6-disphosphate (FDP) for myocardial protection. The parameters of serum myocardial zymogram, ECG and cardiac blood flow were measured and the effects of PI and FDP in patients of serious condition were compared. ResultsChange of serum myocardial zymographic parameters was indirectly proportional to the severity of childrens condition. The reduction of myocardial contractive function was demonstrated by the change of cardiac blood flow parameters in Ultrasound Doppler examination (P<0.01). Both PI and FDP had the effect in protecting myocardium and improving heart function, showing insignificant difference between their efficacy (P>0.05), but PI had less stimulation to vessels and without any obvious adverse reaction. ConclusionSevere pneumonia in children can lead to myocardial damage and heart failure, and early applying of myocardial protective measure can significantly improve the prognosis of patient. Myocardial zymographic parameters, especially the CK-MB, are sensitive and important indexes for detecting myocardial injury. PI has effects in protecting myocardium and improving heart function, and therefore, is suitable for spreading and applying in clinical practice. |
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