甲氨喋呤单用及与白芍总甙联用治疗类风湿关节炎的临床疗效比较

目的观察甲氨喋呤联合白芍总甙治疗类风湿关节炎(RA)的临床疗效。方法61例患者分为2组,甲氨喋呤(MTX)组(30例)仅口服MTX治疗,白芍总甙(TGP)+MTX组(31例)口服MTX加TGP治疗,疗程3个月。结果治疗4、8、12周,TGP+MTX组的治疗总有效率分别为90%、94%、100%,略高于MTX组(分别为87%、90%、97%),两组间比较差异无显著性(P>0.05)。两组均能显著降低红细胞沉降率(ESR)、C-反应蛋白水平,但TGP+MTX组更显著。结论TGP+MTX联合方案起效快、疗效稳定、不良反应较少,依从性更高,较适合老年RA患者。

英文摘要:

ObjectiveTo observe the clinical efficacy of methotrexate (MTX) combined with total glucosides of Peony (TGP) on rheumatoid arthritis (RA). Methods Sixty-one RA patients were divided into 2 groups, 30 patients in the MTX group were only administered orally with MTX, while 31 patients in the combined treated group were treated with MTX plus TGP, the therapeutic course for both groups was 3 months. Results The total effective rate was 90%, 94%, 100% in the MTX plus TGP group, and 87%, 90%, 94% in the MTX group at 4, 8 and 12 weeks after treatment respectively, comparison of the therapeutic effect between the two groups showed insignificant difference (P>0.05). The erythrocyte sedimentation rate (ESR) and the level of C-reactive protein were significantly decreased in both groups, but the decrement in the MTX plus TGP group was more than those in the MTX group. Conclusion MTX plus TGP treatment is characterized by quick initiating, with stable clinical efficacy, few side effects and high compliance, it is more suitable for aged RA patients.

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