扶正祛邪颗粒对呼吸道病毒感染人群免疫细胞及因子的影响

作者	单位
董竞成	复旦大学附属华山医院
刘羽华	复旦大学附属华山医院
宫兆华	复旦大学附属华山医院
董晓辉	复旦大学附属华山医院
谢瑾玉	复旦大学附属华山医院
巫善美	复旦大学附属华山医院
崔焱	复旦大学附属华山医院
蔡蓉	上海控江医院
胡燕蓉	上海建工医院
倪勤龙	上海奉贤中心医院
倪世昌	上海奉贤中心医院

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中文摘要:

目的观察扶正祛邪颗粒对呼吸道病毒感染人群免疫细胞及细胞因子的影响。方法59例患者随机分为3组,即治疗组(19例,用常规西药加中药治疗)、西药组(19例,单用常规西药治疗)和中药组(21例,单用中药治疗),分别于治疗前、治疗1周和2周测定T淋巴细胞亚群、白细胞介素(IL2、4、6、10)、肿瘤坏死因子α(TNFα)、干扰素γ(IFNγ)及Th1/Th2比值的变化。结果3组患者治疗前TNFα、IL2、IL6、IL10和IFNγ水平均比健康人明显升高(P<0.05),治疗1周时血清TNFα、IL6、IL10水平比治疗前明显降低(P<0.05);西药组血清IL2和IFNγ于第2周时已降至正常,治疗组及中药组至第2周时血清IL2和IFNγ浓度仍保持较高水平(P<0.05)。血清IL4水平3组治疗前后比较差异无显著性。治疗第2周时治疗组和中药组Th1/Th2比值比西药组和治疗前升高(P<0.05);3组T淋巴细胞亚群(CD3+、CD4+、CD8+)和分类(B和NK)细胞百分比治疗前后比较差异无显著性。结论扶正祛邪颗粒在一定程度上能正面调节上呼吸道病毒感染人群的免疫功能。

英文摘要:

ObjectiveTo investigate the effect of Fuzheng Quxie granule (FQG) on immune cells and cytokines in populations with respiratory viral infection. MethodsFifty-nine patients were randomly divided into 3 groups, that is, 19 patients treated with conventional western medicine (WM) plus FQG in the treated group, 19 patients treated with conventional western medicine alone in the WM group, and 21 patients treated with FQG alone in the TCM group. The levels of T lymphocyte subsets, interleukine-2,4,6,10 (IL-2, IL-4, IL-6, IL-10), tumor necrosis factor-α(TNF-α), interferon-γ(INF-γ) and Th1/Th2 were determined before treatment, and at the end of 1st and 2nd week of treatment respectively. ResultsBefore treatment, levels of TNF-α,IL-2, IL-6, IL-10 and INF-γ in all patients were significantly higher than normal range (P<0.5). After being treated for 1 week, the levels of serum TNF-α, IL-6, and IL-10 were significantly decreased in all groups (P<0.05), serum IL-2 and INF-γ decreased to the normal level in the WM group,but in the treated and the FQG group by the end of the 2nd week, the two indexes still remained at the rather higher level (P<0.05). The ratio of Th1 and Th2 in the treated group and the FQG group increased significantly by the end of 2nd week, reached the level higher than that in the WM group and that before treatment (P<0.5). No significant difference in, T lymphocytes subsets (CD3~+, CD4~+, CD8~+) and percentage of B and NK cells before and after treatment was found in all the 3 groups. ConclusionFQG can positively regulate the immune function of patients with respiratory tract viral infection in certain degree.

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