麦味地黄口服液对激素治疗活动性系统性红斑狼疮的干预作用

作者	单位
杨旭燕	浙江大学医学院附属第二医院风湿科杭州310009
许东航	浙江大学医学院附属第二医院风湿科杭州310009

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中文摘要:

目的观察麦味地黄口服液对激素治疗活动性系统性红斑狼疮(SLE)的干预作用。方法将60例病情处于活动期的SLE患者随机分为治疗组和对照组(各30例),两组均给予泼尼松首始剂量为0.5～1mg/kg,持续6～8周后,根据病情尽可能减量。治疗组同时加服麦味地黄口服液,每次10ml,每天2次,疗程3个月。结果治疗组临床疗效优于对照组(P<0.05)。系统性红斑狼疮活动指数(systemiclupuserythematosusdiseaseactivityindex,SLEDAI)两组均显著改善(P<0.01),且以治疗组为优(P<0.05),激素用量治疗组比对照组明显减少(P<0.01)。阴虚火旺证候积分值治疗组明显降低(P<0.01),而对照组无明显变化(P>0.05),两组比较差异有显著性(P<0.01)。不良反应的发生率治疗组较对照组低(P<0.05)。结论麦味地黄口服液能提高激素对SLE疗效,并减少激素用量,可对抗激素的不良反应。

英文摘要:

ObjectiveTo observe the intervention of Maiwei Dihuang Oral Liquid (MDOL) on hormonotherapy in treating active systemic lupus erythematosus (SLE).MethodsSixty SLE patients in active stage were randomly and equally allocated into two groups, and administered with prednisone, which was medicated in initial dose of 0.5—1mg/kg, and with the dose being reduced conditionally 6—8 weeks. To the 30 patients in the treated group 10 ml MDOL twice daily was given additionally.The therapeutic course was 3 months. ResultsThe therapeutic effect in the treated group was better than that in the control group (P<0.05). Systemic lupus erythematosus disease activity index (SLEDAI) was significantly improved in both groups (P<0.01), but was superior in the treated group (P<0.05). The dose of prednisone used was significantly reduced (P<0.01), and the scores of Yin-deficiency fire-flourishing syndrome were obviously decreased (P<0.01) in the treated group while in the control group, these indexes were unchanged (P>0.05), the difference between the two groups was significant (P<0.01). The occurrence of adverse reaction was significantly lower in the treated group than that in the control group (P<0.05). ConclusionMDOL can obviously improve the effect of hormonotherapy in SLE, it has advantages in reducing the dosage used and antagonizing the adverse reactions of glucocorticoid.

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