参松养心胶囊对冠心病室性早搏疗效及心脏自主神经功能的影响

Effect of Shensong Yangxin Capsule on Ventricular Premature Beat and Cardiovascular Autonomic Nervous Function in Patients with Coronary Heart Disease

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DOI：

中文关键词: 参松养心胶囊心脏自主神经功能心率变异冠心病室性早搏

英文关键词:Shensong Yangxin capsule cardiovascular autonomic nervous function heart rate variability coronary heart disease ventricular premature beat

基金项目:国家科技部创新基金资助项目(No.02C26221300024)

作者	单位
谷春华	河北以岭医药研究院
吴以岭	河北医科大学医药研究院
田书彦	河北以岭医药研究院
高学东	河北以岭医药研究院
齐晓琳	河北以岭医药研究院
贾振华	河北以岭医药研究院
杨立波	河北以岭医药研究院
李云鹏	河北以岭医药研究院
徐贵成	中国中医研究院广安门医院

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中文摘要:

目的观察参松养心胶囊对冠心病室性早搏(气阴两虚、心络瘀阻型心悸)疗效及心脏自主神经功能的影响。方法采用随机双盲、平行对照法按3∶1比例随机分组,与心律宁片(苦参总碱)对照观察,病例完成治疗组165例,对照组56例,疗程均为4周。结果两组冠心病室性早搏和中医证候疗效比较,治疗组高于对照组(P<0.01)。治疗后两组心率变异(HRV)和QT离散度(QTd)均有一定的改善;两组间SDNN、SDANN、SDNNIndex、PNN50变化值比较差异有显著性(P<0.05,P<0.01),治疗组疗效高于对照组。结论参松养心胶囊对冠心病室性早博和中医证候有明显疗效,对心脏自主神经功能活动有明显改善作用。

英文摘要:

ObjectiveTo observe the clinical efficacy of Shensong Yangxin capsule (SYC) on ventricular premature beat (VPB) differentiated in TCM as palpitation of Qi-yin deficiency syndrome or Xin collateral stagnation syndrome, and cardiovascular autonomic nervous function in patients with coronary heart disease (CHD). MethodsThe randomized, double-blind, parallel contrast method was adopted, patients were randomly assigned by 3∶1 ratio into two groups. One hundred and sixty-five patients in SYC treated group and 56 in the control group(treated with Xinlvning tablet), and the therapeutic course for both groups was 4 weeks. ResultsThe clinical efficacy on VPB and in improving TCM syndromes was better in SYC group than that in the control group (P<0.01). After treatment, the heart rate variability (HRV) and QT dispersion in the two groups were improved in a certain degree. The changes of SDNN, SDANN, SDNN Index and PNN 50 in the two groups were significantly different (P<0.05,P<0.01), the efficacy in the treated group was superior to that in the control group. ConclusionSYC has definite effect on VPB and TCM Syndromes, it can obviously meliorate the activity of cardiovascular autonomic nervous system in the patients with CHD.

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