不稳定斑块的中西医结合认识现状及研究思路

作者	单位
张京春	中国中医研究院西苑医院
陈可冀	中国中医研究院西苑医院
张文高	山东中医药大学
史大卓	中国中医研究院西苑医院

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中文摘要:

动脉粥样硬化(AS)稳定斑块向不稳定的转变与心脑血管疾病事件密切相关,如何稳定AS斑块成为现代心脑血管疾病防治研究的热点。粥样斑块的形成是一个由多种因素参与的漫长复杂的过程,炎性反应在不稳定斑块形成及破裂中起着重要作用,中医药多途径、多环节、多靶点全方位治疗疾病且不良反应轻的特点,应该在稳定AS斑块方面具有潜在的疗效优势。本文就近年来学者们进行的不稳定斑块中西医结合的相关研究作了较为系统的回顾,并结合作者进行的相关课题研究,提出了关于“毒、瘀致不稳定斑块”的设想,且正在运用解毒活血的方法进行不稳定斑块干预的研究。相信通过这一探索性研究工作,会为稳定AS斑块中医药治疗方法学提供客观的实验及临床基础。

英文摘要:

The changing of atherosclerosis (AS) plaque from stable to unstable is closely related to the incidence of cardio-cerebrovascular events. So, to stabilize AS plaque become the hot point of the modern study on prevention and treatment of cardio-cerebrovascular diseases. The formation of AS plaque is a very long and complicated process with the participation of many factors. However, inflammation reaction plays an important role in the formation and rupture of unstable plaque. Traditional Chinese medicine (TCM) shows latent therapeutic advantages in stabilizing AS plaque with its characteristics of multi-way, multi-link, and multi-target point and all-sided treatment as well as its rather milder adverse reactions. The paper gives a comparatively systematic retrospection of study on unstable plaque treated by integrated Chinese and Western medicine conducted in recent years. Combined with the related topics conducted by the authors, they raise the theory of “unstable plaque is induced by toxin and stagnation ", and introduce the study on the intervention of unstable plaque by removing toxic substances and activating blood flow. They believe that the explorative study can provide objective experimental and clinical basis for TCM therapeutic method in stabilizing AS plaque.

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