| 杨大国,李知玉,邓欣,李晓良,聂广,何清.正肝方治疗肝硬化伴高甲胎蛋白血症的近期疗效观察[J].中国中西医结合杂志,2005,(10):931-933 |
| 正肝方治疗肝硬化伴高甲胎蛋白血症的近期疗效观察 |
| Observation on Short-term Therapeutic Effect of Zhenggan Recipe in Treating Liver Cirrhosis with Alpha-fetoprotein |
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| DOI： |
| 中文关键词: 肝硬化 肝癌前病变 中医药疗法 正肝方 |
| 英文关键词:liver cirrhosis precancerous lesion of liver traditional Chinese medicinal therapy Zhenggan Recipe |
| 基金项目:广东省深圳市科技局课题(No.200304202) |
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| 中文摘要: |
| 目的观察中药正肝方治疗肝硬化伴高甲胎蛋白(AFP)患者的临床疗效,并探讨其疗效机理。方法64例肝硬化伴高AFP患者,随机分为正肝方治疗组和对照组。对照组给予常规西药综合治疗,正肝方治疗组在常规西药综合治疗基础上,加用中药正肝方,每天1剂,每天2次口服,疗程6个月。观察两组患者治疗前后肝功能(ALT、GGT、TBIL、ALB)、AFP值、CD4、CD4/CD8值及肝脏影像学检查情况,比较各组治疗效果。结果正肝方能有效降低患者AFP水平(P<0·01),升高患者CD4、CD4/CD8值(P<0·01或P<0·05)。结论正肝方能有效降低AFP水平,其机理可能与提高患者的细胞免疫功能有关。 |
| 英文摘要: |
| ObjectiveTo observe the therapeutic effect of Zhenggan Recipe （ZGR） in treating liver cirrhosis with abnormal Alpha-fetoprotein （AFP）, and to explore its mechanism. MethodsSixty-four patients of liver cirrhosis with abnormal AFP were randomly divided into the treated group and the control group. All the patients received conventional combined Western medicinal treatment. Besides, additional ZGR was given to the patients in the treated group, one dose every day for orally taken in two times, 6 months as a therapeutic course. Changes in liver function （ALT, GGT, TBIL and ALB）, AFP, T-lymphocyte subsets （CD4, CD4/CD8） and iconological examination were observed in the two groups before and after treatment to compared the efficacy. ResultsZGR could effectively lower the AFP level （P<0.01）,and improve the levels of CD4 and CD4/CD8 （P<0.01 or P<0.05）.ConclusionZGR can effectively lower the level of AFP, its mechanism might be related to the improving of cellular immune function of the patients. |
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