黄芪注射液对系统性红斑狼疮患者细胞凋亡和免疫功能的影响

作者	单位
蔡小燕	广州市第一人民医院广州510180
许艳丽	广州市第一人民医院广州510180
林小军	广州市第一人民医院广州510180
傅君舟	广州市第一人民医院广州510180
秦曙光	广州市第一人民医院广州510180
李剑文	广州市第一人民医院广州510180

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中文摘要:

目的研究黄芪注射液对系统性红斑狼疮(SLE)细胞凋亡和免疫功能的影响,探讨其对系统性红斑狼疮的治疗作用。方法将80例初发SLE患者随机分为常规治疗组和黄芪治疗组(在常规治疗的基础上加用黄芪注射液)。观察两组患者治疗前后外周血淋巴细胞上Fas、Bcl-2抗原的表达和T淋巴细胞亚群的变化。结果两组患者治疗后外周血淋巴细胞上Fas抗原的表达下调(P<0·01),Bcl-2抗原的表达以及CD4+亚群、CD4+/CD8+比值上升(P<0·01);其中,治疗后Fas抗原表达的下调、CD4+亚群及CD4+/CD8+比值的上升,黄芪治疗组更显著(P<0·05)。结论黄芪注射液在一定程度上增加了激素或免疫抑制剂对细胞凋亡的抑制作用,调节T淋巴细胞亚群比例和功能趋于正常,可以作为提高系统性红斑狼疮疗效的重要治疗措施。

英文摘要:

ObjectiveTo investigate the effect of Radix Astragali Injection on apoptosis of lymphocytes and immune function in treating patients with systemic lupus erythematosus （SLE）. MethodsEighty SLE patients were randomly assigned into the routine treatment group （RT） treated with conventional therapy and the Radix Astragali treated group （RA） treated with Radix Astragali Injection besides routine treatment. The expressions of Fas and Bcl-2 antigen on lymphocytes and the changes of T lymphocyte subsets in peripheral blood before and after treatment were observed. Results After treatment, the expression of Fas antigen on lymphocytes significantly lowered （P<0.01）, and that of Bcl-2 antigen, CD₄⁺ lymphocyte subset and CD₄⁺/ CD₈⁺ ratio significantly increased in both groups （all P<0.01）. However, the changes of Fas antigen expression, CD₄⁺ and CD₄⁺/ CD₈⁺ ratio were more significant in the RA group than those in the RT group （P<0.05）. ConclusionRadix Astragli Injection can enhance the inhibitory function of corticosteroid/immunosuppressant on apoptosis, and regulate the ratio and function of T lymphocyte subsets to normal range, which may be a useful approach for enhancing the efficacy of treatment to SLE.

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