稳心颗粒和胺碘酮合用对房颤患者复律的临床疗效及安全性

作者	单位
王敏	浙江省中西医结合医院心内科杭州310003
余逸波	浙江省中西医结合医院心内科杭州310003
黄世恩	浙江省中西医结合医院心内科杭州310003
姚强	浙江省中西医结合医院心内科杭州310003
沈建瑾	浙江省中西医结合医院心内科杭州310003

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中文摘要:

目的观察稳心颗粒和胺碘酮合用对房颤患者复律的临床疗效和安全性。方法将224例心房颤动(房颤持续时间≤1年)患者随机分成两组:治疗组(稳心颗粒和胺碘酮合用)112例和对照组(胺碘酮单用)112例,观察两组口服药物6个月内房颤累积复律率及不良反应。结果6个月内治疗组3例退出,完成观察109例;对照组5例退出,完成观察107例。治疗组与对照组比较,房颤累积复律率1个月时即显示差异有显著性(P<0·05),6个月时分别为65·1%、47·7%(P<0·05),房颤复律患者的平均复律时间,平均胺碘酮用量,不良反应发生率,两组比较差异均有显著性(P<0·05)。结论稳心颗粒和胺碘酮合用较胺碘酮单用既可提高房颤复律率,又可缩短复律时间和减少胺碘酮用量从而减少胺碘酮长期应用所致的不良反应。

英文摘要:

ObjectiveTo observe the clinical effect of the combined use of amiodarone and Wenxin Granule (WXG) in auricular fibrillation (AF) conversion and its safety. MethodsTwo hundred and twenty-four patients, in whom AF lasted for less than 1 year, were enrolled and randomly assigned into two groups, 112 in each group. Patients in the treated group were treated with WXG and amiodorane and the others in the control group were orally administered with amiodarone alone. The accumulative conversion rate of AF and adverse reaction were monitored during the 6-month observation period. ResultsSix-month observation was completed in 109 cases in the treated group and 107 in the control group, while 3 cases and 5 cases in the two groups were dropped out respectively. The difference of accumulative AF conversion rates between the two groups become significant early after one month medication (P<0.05), and was 65.1% and 47.7% respectively after 6-month of treatment (P<0.05). Inter-group significant difference was also shown in the aspects of average conversion time, dosage of amiodarone required and the occurrence of adverse reaction (P<0.05). ConclusionCombined use of WXG and amiodarone has a better effect in improving conversion rate of AF, shortening conversion time and decreasing the required dosage of amiodarone in treating AF as compared with the treatment with amiodarone alone, and by which the adverse reaction of long-term using amiodarone could be avoided.

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