葛根芩连汤配合胰岛素强化治疗湿热证2型糖尿病临床观察

Effect of Gegen Qinlian Decoction Combined with Short-term Intensive Insulin Treatment on Patients with Type 2 Diabetes Mellitus of Dampness-Heat Syndrome

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DOI：

中文关键词: 2型糖尿病湿热证胰岛素强化治疗葛根芩连汤

英文关键词:type 2 diabetes mellitus dampness-heat syndrome insulin intensive treatment Gegen Qinlian Decoction

基金项目:

作者	单位
曾艺鹏	上海市南汇区中心医院内分泌科
黄云胜	上海中医药大学
胡蕴刚	上海市南汇区中心医院内分泌科
王爱华	上海市南汇区中心医院内分泌科

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中文摘要:

目的观察伴湿热证的2型糖尿病,经胰岛素强化血糖控制、并联合葛根芩连汤加味对湿热证候的疗效及胰岛素用量的影响。方法中药组以葛根芩连汤加味配合胰岛素强化治疗,常规组单予胰岛素强化治疗。结果中药组14例,显效5例,有效6例,无效3例,总有效率为78．6％;常规组16例,显效2例,有效7例,无效7例,总有效率56．3％;两组比较,差异有显著性(u=2．58,P<0．01)。经胰岛素强化治疗血糖达标时间(天)中药组(4．54±0．50)较常规组(5．31±0．57)短(P<0．01);治疗结束时胰岛素用量较血糖达标时中药组减少(9．07±6．51)U,常规组减少(4．38±5．94)U;两组比较,差异有显著性(P<0．05)。结论对伴湿热证的2型糖尿病,在短期胰岛素强化治疗基础上,联合葛根芩连汤加味治疗,可以相对减少胰岛素用量,并取得较好的临床疗效。

英文摘要:

Objective To observe the effect of Gegen Qinlian Decoction (GQD) in combination with short-term intensive insulin treatment on type 2 diabetes mellitus (T2DM) of dampness-heat syndrome and its influence on dosage of insulin used. Methods The GQD group (n=14) was treated by GQD and insulin, while the conventional group (n=16) was given insulin intensive treatment alone. Results In the GQD group, the treatment was markedly effective in 5 patients, effective in 6 and ineffective in 3, the total effective rate being 78.6 % , much better than that in the conventional group (2,7,7 and 56.3% respectively, u=2.58, P<0.01). And it took less time for controlling blood glucose (BG) in the GQD group (4.54±0.50 days) than that in the conventional group (5.31±0.57 days, P<0.01); Furthermore, by the end of the treatment course, as compared with that at the time just after BG being controlled, the daily average insulin dosage used in the GQD group reduced by 9.07±6.51 U, while it was only 4.38±5.94 U in the conventional group, showing significant difference between them (P<0.05). Conclusion Based on short-term insulin intensive treatment, the combined using of GQD could reduce the dosage of insulin used and shows better clinical curative effect for patients with T2DM of dampness-heat syndrome.

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