不同剂量参附注射液预防ST段上抬型急性心肌梗死并发心衰的临床研究

Clinical Research on Effects of Shenfu Injection in Different Dosage in Preventing Heart Failure Occurred in Patients of Acute Myocardial Infarction with Elevated ST Segment

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DOI：

中文关键词: 参附注射液 ST段上抬急性心肌梗死心力衰竭并发症

英文关键词:Shenfu Injection ST segment elevation acute myocardial infarction heart failure complication

基金项目:

作者	单位
李泽恩	广州市中医医院急诊科广州510130

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中文摘要:

目的研究不同剂量参附注射液对ST段上抬型急性心肌梗死(STEMI)所致心衰并发症的预防作用。方法STEMI患者97例,分为西医对照组、参附小剂量组及参附大剂量组,对照组采用西医常规治疗,参附小剂量及大剂量组在西医常规治疗的基础上,分别静脉注射0．3ml／(kg·d)、0．6ml／(kg·d)的参附注射液,14天后比较3组心衰发生率,并按心功能Killip分级标准比较心衰严重程度。结果3组患者的心衰发生率差异无显著性,但参附小剂量组和参附大剂量组的心衰严重程度明显轻于对照组,差异有显著性,且参附大剂量组的疗效优于参附小剂量组。结论在西医常规治疗的基础上使用参附注射液有助于减轻心衰并发症的严重程度。

英文摘要:

Objective To study the preventive effect of Shenfu Injection (SI) in different dosage on occurrence of heart failure in patients of acute myocardial infarction (MI) with elevated ST segment. Methods Ninety-seven patients of MI were divided into 3 groups, all were treated with conventional therapy, but to the SI treated groups, intravenous injection of low (0.3 ml/kg) or high dose (0.6 ml/kg) of SI were given once a day additionally. After 14 days’ treatment, the incidence of heart failure and its severity were observed and evaluated with Killip grading. Results There was no significant difference in the incidence of heart failure among the 3 groups, but the severity of heart failure in the SI treated groups was remarkably milder than that in the control group, and the high dose SI showed the effect superior to that of low dose SI. Conclusion Based on the conventional treatment, Shenfu Injection is helpful for alleviating the severity of heart failure.

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