中药扶正胶囊和祛邪胶囊减少Ⅱ、Ⅲ期大肠癌术后复发转移的队列研究

Cohort Study on Fuzheng Capsule and Quxie Capsule in Reducing Relapse and Metastasis of Cancer in Patients with Stage Ⅱ and Ⅲ Colorectal Carcinoma after Operation

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DOI：

中文关键词: 扶正胶囊和祛邪胶囊大肠癌复发转移队列研究

英文关键词:Fuzheng Capsule and Quxie Capsule colorectal cancer relapse and metastasis cohort study

基金项目:

作者	单位
雒琳	中国中医科学院西苑医院肿瘤科
杨宇飞	中国中医科学院西苑医院肿瘤科
李培红	中国中医科学院西苑医院药剂科
吴煜	中国中医科学院西苑医院肿瘤科
张建伟	北京军区总医院肿瘤科
吴显文	中国中医科学院西苑医院肿瘤科
高书棣	中国中医科学院西苑医院药剂科
刘端祺	北京军区总医院肿瘤科

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中文摘要:

目的探讨在Ⅱ、Ⅲ期大肠癌根治术及常规化疗放疗后应用中药扶正胶囊和祛邪胶囊减少复发转移的临床价值。方法采用前瞻性队列研究设计,选取101例大肠癌根治术及常规化疗放疗后Ⅱ、Ⅲ期患者,进行同期队列对照,其中治疗组53例,应用扶正胶囊及祛邪胶囊治疗,对照组48例,不加特殊干预,只定期随访,观察两组1、2、3年复发转移率及复发转移时间。结果治疗组1、2、3年复发转移率分别为0、2.7%、14.8%,对照组为6.2%、24.2%、30.8%,两组比较2年复发转移率差异有显著性(χ2=5.428,P<0.05),1年、3年复发转移率差异无显著性(P>0.05);治疗组出现复发转移的平均时间为(26.2±4.5)个月,而对照组为(14.2±4.2)个月,差异有显著性(P<0.05)。结论扶正胶囊和祛邪胶囊在根治术后Ⅱ、Ⅲ期大肠癌的后续巩固治疗中可能有减少复发转移,改善生活质量的作用,值得进一步进行随机对照临床研究。

英文摘要:

ObjectiveTo study the effect of Fuzheng Capsule (FC) and Quxie Capsule (QC) in reducing relapse and metastasis of colorectal cancer in stage Ⅱ and Ⅲ after the cancer had been treated by radical operation and succedent routine radiotherapy and chemotherapy. MethodsA prospective cohort controlled study was conducted in 101 patients with colorectal cancer in stage Ⅱ and Ⅲ after radical operation and routine radiotherapy and chemotherapy, among whom 53 patients were treated with FC and QC and 48 were given no treatment, they were followed up regularly. The rate and time of relapse and metastasis were observed after 1, 2 and 3 years.ResultsOne-year, 2-year and 3-year relapse-metastasis rate was 0, 2.7% and 14.8% respectively in the treated group, and 6.2%, 24.2% and 30.8% in the control group. Significant difference was found only in the 2-year rate between the two groups (χ~2=5.428,P<0.05). Average time of relapse and metastasis was 26.2±4.5 months in the treated group and 14.2±4.2 months in the control group, showing significant difference between the two groups (P<0.05). ConclusionFC and QC applying in the succedent consolidating treatment for stage Ⅱ and Ⅲ colorectal cancer after radical operation might be favourable to reduce relapse and metastasis and improve quality of life, further clinical study with randomized and controlled method is worthwhile to be conducted.

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