| 李莉,袁海龙,吴勤,韩萍,黄辉煌,李梵,臧红.肝能滴丸治疗慢性乙型肝炎的临床研究[J].中国中西医结合杂志,2006,(9):788-790 |
| 肝能滴丸治疗慢性乙型肝炎的临床研究 |
| Clinical Study on Effect of Ganneng Dripping Pill in Treating Chronic Hepatitis B |
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| DOI： |
| 中文关键词: 慢性乙型肝炎 肝能滴丸 拉米夫定 抗病毒 |
| 英文关键词:chronic hepatitis B Ganneng Dripping Pill lamivudine anti-viral therapy |
| 基金项目:北京市重大创新基金资助项目(No.D0204003040931) |
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| 中文摘要: |
| 目的观察中药肝能滴丸治疗慢性乙型肝炎患者临床抗病毒疗效。方法选取乙肝病毒主要复制指标HBV-DNA、HBsAg、HBeAg阳性慢性乙型肝炎患者共84例,开放随机分为肝能滴丸治疗组56例和拉米夫定对照组28例,疗程0·5年;观察两组患者血清HBeAg、HBV-DNA的阴转率和肝功能、症状、体征变化情况。结果治疗组HBV-DNA阴转率为54·0%(27/50例)、HBeAg阴转率30·0%(15/50例)、ALT复常率80·0%(40/50例);对照组依次为67·9%(19/28例)、21·4%(6/28例)、75·0%(21/28例);两组比较差异均无显著性(均P>0·05)。治疗组AST复常率98·0%(48/49例),对照组为48·0%(12/25例),两组比较差异有显著性(P<0·01)。治疗组症状改善以胁肋胀痛、纳食减少、倦怠乏力、脘闷腹胀、尿黄最为显著,明显优于治疗前(P<0·05或P<0·01)。结论肝能滴丸对慢性乙型肝炎有较好的近期疗效;能有效抑制HBV复制,改善肝功能及症状体征。 |
| 英文摘要: |
| ObjectiveTo observe the antiviral efficacy of Ganneng Dripping Pill (GDP) in treating patients with chronic hepatitis B. Methods Eighty-four patients of chronic hepatitis B with positive HBV-DNA, HBsAg, and HBeAg were randomly assigned to 2 groups, the treated group (56 patients) treated with GDP and the control group (28 patients) treated with lamivudine. The therapeutic course for both groups was 6 months. The negative conversion rate of HBeAg and HBV-DNA, changes of liver function, symptoms and physical signs in patients were observed before and after treatment. ResultsIn the treated group, the negative conversion rate of HBV-DNA and HBeAg was 54.0% (27/50) and 30.0% (15/50) respectively, and the ALT normalizing rate was 80.0%(40/50), while those were 67.86%(19/28), 21.8% (6/28) and 75.0% (21/28) respectively in the control group, showing no significant difference between the two groups (all P>0.05). However, the AST normalizing rate was 97.96% (48/49) in the treated group, higher than that in the control group (48.0%, 12/25, P<0.01); and the clinical symptoms, especially the poor appetite, lassitude, gastric distention and yellow urine, were improved more significantly in the treated group than those in the control group (P<0.05 or P<0.01). ConclusionGDP has a favorable short-term effect on chronic hepatitis B, it could effectively inhibit HBV replication and improve the liver function, symptoms and signs in patients. |
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