通降颗粒对大鼠实验性反流性食管炎的疗效评价研究

作者	单位
唐旭东	中国中医科学院西苑医院
吴红梅	中国中医科学院广安门医院
王志斌	北京市药品检验所
邵燕	北京市药品检验所
胡宇驰	北京市药品检验所

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中文摘要:

目的阐明通降颗粒治疗大鼠实验性反流性食管炎的疗效。方法首先分别采用贲门成形+幽门结扎+胃空肠Roux-en-Y吻合术、贲门钢圈置入固定术建立大鼠实验性食管炎模型,再分别给予不同剂量的通降颗粒及对照药普瑞博思(西沙必利)灌胃治疗。结果造模成功,两种造模组的大鼠给药治疗后均表明通降颗粒浸膏大剂量组与模型组的食管黏膜组织病理积分比较差异有显著性(P<0.05),但与西药对照组比较差异无显著性;透射电镜结果显示通降颗粒浸膏大、中剂量组有减轻棘细胞破坏及炎症反应的作用;通降颗粒可降低实验性RE大鼠的胃酸水平,以中药大、中剂量组作用显著(P<0.05);西药组无明显降低胃酸作用。结论通降颗粒浸膏对大鼠实验性反流性食管炎有一定的治疗作用。

英文摘要:

ObjectiveTo study the effects of Tongjiang Granule (TJG) on reflux esophagitis (RE) in rats. MethodsTwo rat models of RE were established respectively by cardioplasty+pyloric ligation+ Roux-en-Y gastro-jejunum anastomosis and by placed a fixed steel ring into the gastric cardia, and the model rats were treated with various dosages of TJG or cisapride by gastric perfusion. ResultsRat models were established successfully by both methods. The score of pathological changes of esophagus mucosa in the model rats, made by either method, after high-dosage TJG treatment was lower than that in the model rats (P<0.05), but equal to that in the cisapride treated model rats. High and moderate dosages of TJG were shown by transmission electron microscope to have effects of alleviating heckle cells and inflammatory reaction. They could reduce the level of gastric acid, more significant in high and moderate dosage groups (P<0.05), while cisapride couldn’t. ConclusionTJG is effective in treating experimental RE in rats to a certain extent.

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