| 邵广瑞,马蕾,柳澄,宋磊,张伟.针刺委中穴正电子发射计算机体层摄影/CT脑功能成像的观察[J].中国中西医结合杂志,2006,(11):969-972 |
| 针刺委中穴正电子发射计算机体层摄影/CT脑功能成像的观察 |
| Effects of Acupuncture at Weizhong (BL40) on Brain Function with PET/CT |
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| DOI： |
| 中文关键词: 针刺 委中穴 发射型计算机 体层摄影术 X线计算机 |
| 英文关键词:acupuncture Weizhong acupoint (BL 40) tomography emission computer X-ray computer |
| 基金项目:山东省中医管理局科研基金资助项目(No.2005-34) |
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| 中文摘要: |
| 目的应用正电子发射计算机体层摄影(PET)/CT脑功能成像技术,观察针刺委中穴在脑内引起的代谢变化,探讨针刺疗法的中枢调节机制。方法电针刺激8名健康志愿者右侧委中穴,同时行PET/CT脑功能成像,采用相同扫描技术对同8名受试者行无任何穴位刺激的PET/CT脑功能成像。使用统计参数图(SPM)的配对t检验模型,对比针刺委中穴组与静息对照组的差异脑功能图。结果根据布劳德曼区(Broadmann area,BA),(1)针刺诱发的平均功能激活脑区:左侧BA10、11、22、38、39、40、44、45、46,右侧BA10,双侧BA19、18以及左侧小脑皮层、屏状核、岛叶(t>3·36,P<0·01,k>30voxels);(2)针刺诱发平均功能抑制脑区:双侧BA24,左侧BA7、8、19、40,右侧BA1、3、6、20、44和左侧黑质。结论委中穴与大脑存在着一定的联系,针刺委中穴是通过激活和抑制有功能联系的多个特异脑功能区,并通过神经体液机制共同发挥作用。其中前额区、岛叶及小脑的功能激活和扣带回、顶叶及黑质的功能抑制分析是针刺委中穴的中枢调节机制之一。本研究证明,PET/CT脑功能成像技术有助于揭示中医经络理论,为针刺疗法提供中枢调节机制的可视性试验依据。 |
| 英文摘要: |
| ObjectiveTo observe the effect of needling at Weizhong (BL 40) acupoint in inducing metabolic changes in brain with positron emission tomography and dynamic contrast (PET/CT) imaging for exploring the mechanism of central regulation of acupuncture. Methods PET/CT was performed before and during needling Weizhong acupoint of right leg by electro-acupuncture in 8 healthy volunteers, and also in other 8 subjects without any acupoint stimulation for control. Difference of brain functional images between the two groups before and during needling was analyzed by pairing t-test with statistical parametric mapping. Results The needling evoked mean activated cerebral functional regions were: left Broadmann area (BA) 10, 11, 22, 38, 39, 40, 44-46, right BA10, bilateral BA18, 19, and left cerebellar cortex, claustrum and insula (t>3.36,P<0.01,k>30 voxels); its mean inhibited brain functional regions were: bilateral BA24, left BA7, 8, 19, 40, right BA 1, 3, 6, 20, 44, and left substantia nigra. Conclusion There is a certain connection between Weizhong acupoint and the brain. Needling this acupoint could exert effects through activating or inhibiting brain function in specific regions and neurohumoral regulation. One of the central regulation mechanisms of acupuncture was functional activation in superior, middle, and inferior frontal gyrus, insula and cerebellum and functional inhibition in callosal gyrus, lobi parietalis and substantia nigra. This study further demonstrated PET/CT is useful in revealing TCM meridian theory and could provide objective proof of central regulation for acupuncture treatment. |
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