凉血解毒、清热化湿和凉血解毒、健脾温阳法治疗慢性重型肝炎的临床观察

Clinical Observation on Chronic Severe Hepatitis B Treated by Principles of Cooling-Blood and Detoxicating Combined with Clearing-Heat and Resolving-Damp or Combined with Strengthening-Pi and Warming-Yang

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中文关键词: 慢性重型肝炎阴阳黄证辨证治疗消退黄疸

英文关键词:chronic severe hepatitis B Yanghuang and Yinhuang syndrome type treatment depending on syndrome differentiation eliminating jaundice

基金项目:

作者	单位
孙克伟	湖南中医药大学第一附属医院肝病中心长沙410007
陈斌	湖南中医药大学第一附属医院肝病中心长沙410007
黄裕红	湖南中医药大学第一附属医院肝病中心长沙410007
伍玉南	湖南中医药大学第一附属医院肝病中心长沙410007
周小青	湖南中医药大学第一附属医院肝病中心长沙410007

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中文摘要:

目的观察凉血解毒、清热化湿法(简称清热化湿法)和凉血解毒、健脾温阳法(简称健脾温阳法)治疗慢性重型肝炎阴阳黄证的初步疗效,为黄疸的中医治疗提供思路。方法采用随机、对照方法,进行中医辨证治疗慢性重型肝炎43例,重点观察比较清热化湿、健脾温阳两法消退黄疸的作用。结果治疗4周后,清热化湿组22例,有效16例(72·7%),无效6例(27·3%);健脾温阳组21例,有效19例(90·5%),无效2例(9·5%);两组疗效比较差异无显著性。TBIL:治疗后两组均下降(P<0·01),且健脾温阳组下降的幅度大于清热化湿组(P<0·05);凝血酶原活动度:健脾温阳组上升幅度优于清热化湿组(P<0·05);ALT:两组均降低(P<0·05),但两组间比较差异无显著性。结论凉血解毒、健脾温阳法治疗慢性重型肝炎阴阳黄证的疗效优于凉血解毒、清热化湿法。

英文摘要:

ObjectiveTo observe the therapeutic efficacy on chronic severe hepatitis B (CSH) patients of Yanghuang and Yinhuang syndrome type by principles of cooling-blood and detoxicating combined with clearing-heat and resolving dampness (PA) or with strengthening-Pi and warming-yang (PB), respectively. Methods Forty-three patients with CSH were randomly divided into two groups, group A (22 cases) treated with PA and group B (21 cases) with PB. The therapeutic efficacy, laying stress on the effect in eliminating jaundice, was observed. Results The efficacy in group B was effective in 19 cases (90.5), and ineffective in 2(9.5), while in group A, effective in 16 (72.7) and ineffective in 6 (27.3). Levels of TBIL and ALT were significantly lower in both groups (P<0.05 or P<0.01), and the descending extent was greater, the thrombinogen activity was higher in group B than that in group A after treatment (P<0.05), no significant difference in ALT was found between the two groups. Conclusion The efficacy of PB is better than that of PA on CSH with Yanghuang and Yinghuang syndrome.

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