痛风患者湿热痹阻和瘀热内郁型与血液流变学及血小板活化功能的相关性研究

Research on Relationship of Syndrome Type and Parameters of Hemorheology and Platelet Activation in Patients with Acute Gout Arthritis of Dampness-heat Blockage Type and Stasis-heat Accumulate Type

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中文关键词: 痛风急性发作期湿热痹阻、瘀热内郁型血液流变学血小板活化功能

英文关键词:acute gout arthritis dampness-heat blockage type and stasis-heat accumulate type hemorrheology platelet activation

基金项目:广东省中医药管理局课题(No.2050050)

作者	单位
邵沛	北京大学深圳医院广东518036
黄星涛	北京大学深圳医院广东518036
张帆	北京大学深圳医院广东518036
谢谦	北京大学深圳医院广东518036
聂李平	北京大学深圳医院广东518036
张涛	北京大学深圳医院广东518036

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中文摘要:

目的探讨痛风急性发作期湿热痹阻、瘀热内郁型与血液流变学、血小板活化功能的相关性。方法选择痛风急性发作期患者40例,健康体检者20例为对照组,以辨证分型、血液流变学、血小板活化功能中GPⅡb-Ⅲa复合物纤维蛋白原受体(PAC-1)和P-选择素(CD62p)检测为指标。结果痛风急性期患者湿热痹阻型(24例)、瘀热内郁型(16例)血液流变学表现为全血黏度中切、全血还原黏度中切、血浆黏度、血沉和血沉方程K值均显著高于对照组(P<0·01),红细胞变形指数均显著低于对照组(P<0·01)。PAC-1和CD62p两型均显著高于对照组(P<0·01),而瘀热内郁型比湿热痹阻型显著升高(P<0·05)。结论痛风急性发作期湿热痹阻、瘀热内郁型与血液流变学及血小板活化功能之间存在着相关性,两型间指标水平的差异可能是痛风出现不同证型的内在因素之一。

英文摘要:

ObjectiveTo study the relationship between syndrome type and the parameters of hemorrheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage (DHB) type and stasis-heat accumulation (SHA) type. Methods Forty patients with acute gouty arthritis were divided into 2 groups according to TCM syndrome differentiation, the DHB group (n=24) and the SHA group (n=16), and 20 healthy people were taken as the control group. Hemorrheological parameters, platelet activating factor (PAC-1) and P-selection (CD62p) in them were detected. Results Plasma viscosity, outcome of erythrocyte sedimentation and K value of its equation, levels of PAC-1 and CD62p were higher, erythrocyte electrophoresis index was significantly lower in gout patients of both types than those in the control group (all P<0.01), and the levels of PAC-1 and CD62p in the SHA group were higher than those in the DHB group (P<0.05). Conclusion DHB type and SHA syndrome type of acute gout arthritis are correlated with parameters of hemorrheology and platelet activation, and the different levels of these pameters showed in the two types, may be the internal factors for their genesis.

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