| 钱先,朱萱萱,陈小永,陈剑梅.补肺清瘀颗粒对硬皮病模型小鼠皮肤软化的作用[J].中国中西医结合杂志,2006,(11):1018-1020 |
| 补肺清瘀颗粒对硬皮病模型小鼠皮肤软化的作用 |
| Effect of Bufei Qingyu Granule in Mollifying Skin of Mouse Scleroderma Model |
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| DOI： |
| 中文关键词: 关健词补肺清瘀颗粒 硬皮病小鼠模型 病理学检查 脏器指数 |
| 英文关键词:Bufei Qingyu Granule scleroderma mouse model pathological examination index of organs |
| 基金项目:江苏省科委2000年资助课题(No.BS2000079) |
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| 中文摘要: |
| 目的探讨中药补肺清瘀颗粒对硬皮病模型小鼠皮肤软化的作用。方法对8周龄BALB/C小鼠用博莱霉素制作硬皮病模型,用不同剂量的补肺清瘀颗粒治疗26天,观察各组小鼠皮肤的改善情况。结果补肺清瘀颗粒低、中、高剂量均有改善模型小鼠硬皮病真皮增厚的趋势,中、高剂量能减轻真皮小血管周围炎,缓解附属结构毛囊、汗腺的减少或缺失。中药3个剂量组脾脏指数明显低于模型组(P<0·05)。结论补肺清瘀颗粒能使模型小鼠的皮肤硬化得到改善,并能防止脾脏肿大。 |
| 英文摘要: |
| ObjectiveTo investigate the effect and mechanism of Bufei Qingyu Granule (BQG) in mollifying the skin of scleroderma model mice. Methods Scleroderma model induced with bleomycin in BALB/C mice 8-weeks old were administered with different dose of BQG for 26 days. The pathological changes of the mice skin were observed. Results Treatment with low, medium and high dose of BQG showed a tendency to ameliorate the thickened dermis in scleroderma mice but without statistical significance. Medium and high dose of BQG reduced the perivasculitis of dermis and alleviated the reduction or deletion of accessory structure, such as hair follicle and sweat gland. And the spleen index was lower markedly in mice treated with BQG of any dose than that in the untreated model mice (P<0.05). Conclusion BQG could ameliorate the sclerosed skin in model mice and prevent the occurrence of splenomegaly. |
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