化湿中药对慢性乙型肝炎湿证患者激活和功能T淋巴细胞亚群水平的影响

Effect of Chinese Medicine for Resolving Dampness on Activated and Functional T Lymphocyte Subsets in Chronic Hepatitis B Patients with Dampness Syndrome

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中文关键词: 慢性乙型肝炎湿证激活T淋巴细胞亚群功能T淋巴细胞亚群

英文关键词:chronic hepatitis B dampness syndrome activated T lymphocyte subsets functional T lymphocyte subsets

基金项目:广东省中医药管理局基金资助课题(No.1050172,100108)

作者	单位
张诗军	中山医科大学附属第一医院
陈泽雄	中山医科大学附属第一医院
林佑武	中山医科大学附属第一医院
张瑜	中山医科大学附属第一医院
程永华	中山医科大学附属第一医院
黄必军	中山医科大学肿瘤医院

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中文摘要:

目的探讨化湿中药对慢性乙型肝炎(chronichepatitisB,CHB)湿证患者临床疗效与激活和功能T淋巴细胞亚群水平变化的关系。方法将CHB湿证患者75例非随机分为两组,治疗组(45例)采用化湿中药治疗,对照组(30例)采用核苷类似物治疗,观察治疗1年后两组临床疗效及激活和功能T淋巴细胞亚群水平变化。结果CHB患者外周血CD8+CD2+8、CD4+CD2+8T细胞水平与健康人比较均明显下降(P<0.01);CD8+CD3+8T细胞水平与健康人比较均明显升高(P<0.05);经治疗后,治疗组CD4+CD2+8、CD8+CD2+8T细胞水平较治疗前明显升高(P<0.05),CD8+CD3+8T细胞水平较治疗前明显下降(P<0.05),对照组CD8+CD3+8T细胞水平较治疗前明显下降(P<0.05)。两组总有效率及显效率相比较,差异无显著性(P>0.05)。CHB显效患者治疗后CD8+CD2+8、CD4+CD2+8T细胞水平明显升高(P<0.05),CD8+CD3+8T细胞水平较治疗前明显下降(P<0.05);非显效患者治疗前后CD8+CD2+8、CD4+CD2+8、CD8+CD3+8、CD4+CD2+5T细胞水平无明显变化(P>0.05)。结论化湿中药对CHB湿证患者激活和功能T淋巴细胞亚群水平有一定的调节作用,这可能是抑制病毒复制、清除病毒的重要途径。

英文摘要:

ObjectiveTo explore the relation between the effect of Huashi Decoction(HD)and levels of activated and functional T lymphocyte subsets in chronic hepatitis B(CHB)patients of dampness syndrome(DS).Methods Seventy CHB patients were nonrandomly assigned to two groups,the treated group(n=45)treated by HD and the control group(n=30)by nucleotide analogies.The clinical efficay was observed and levels of activated and functional T lymphocyte subsets were detected before and after treatment.Results The peripheral blood levels of CD+8CD+ 28 and CD+4CD+ 28T cells were significantly lower in CHB patients than those in the healthy subjects(P<0.01),which were higher in the treated group after treatment compared with those before treatment(P<0.05),while the CD+8CD+ 38 T cell level was significantly higher in CHB patients than in the healthy subjects(P<0.05),which was lower in the treated and the control groups after treatment than those before treatment respectively(P<0.05).No significant difference was found in the markedly effective rate and total effective rate between the two groups(P>0.05).The levels of CD+8CD+ 28 and CD+4CD+ 28 T cells increased and the CD+8CD+38 and CD+4CD+ 25 T cell level decreased obviously after treatment in those who acquired marked effectiveness(P<0.05),while they changed insignificantly in those who did not acquire marked effectiveness(P>0.05).Conclusion HD is effective in regulating activated and functional T lymphocyte subsets in CHB patients with DS,which might be its mechanism of inhibiting virus replication and eliminating virus.

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