益气活血中药血液透析液对慢性肾功能衰竭患者血小板膜糖蛋白CD62P表达的影响

Effect of Hemodialysis with Chinese Herbs of Supplementing Qi and Activating Blood Circulation on Platelet Membranous Glycoprotein CD62P in Patients with Chronic Renal Failure

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中文关键词: 益气活血中药血液透析血小板膜糖蛋白CD62P

英文关键词:Chinese herbs of replenishing qi and activating blood circulation hemodialysis platelet membranous glycoprotein CD62P

基金项目:广东省科技重点攻关项目资助(No.2002C30804)

作者	单位
韦芳宁	广东省中医院肾内科
杨霓芝	广东省中医院肾内科
黄宪章	广东省中医院二沙岛分院检验科
丁海明	广东省中医院二沙岛分院检验科
庄俊华	广东省中医院二沙岛分院检验科

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中文摘要:

目的探讨益气活血中药血液透析液对慢性肾功能衰竭(CRF)患者血小板膜糖蛋白CD62P表达的影响。方法维持性血液透析患者40例随机分为西药组和益气活血中药组,采用ELISA方法检测两组患者血液透析前后血小板膜糖蛋白CD62P的含量。结果两组治疗后与治疗前比较,血尿素氮、肌酐、钾离子、红细胞压积、血小板计数、二氧化碳结合力水平,差异均有显著性(P<0.05);血小板膜糖蛋白CD62P的表达差异有显著性(P<0.05),两组治疗后比较差异亦有显著性(P<0.05)。两组中医症候疗效比较,差异无显著性(P>0.05)。结论益气活血中药血液透析可以改变血小板膜糖蛋白CD62P表达,可能与中药治疗CRF有关。

英文摘要:

ObjectiveTo explore the effects of dialysate contained Chinese herbs for replenishing qi and activating blood circulation on platelet membranous glycoprotein CD62P in patients with chronic renal failure（CRF）undergoing hemodialysis.MethodsForty patients underwent maintaining hemodialysis were randomly assigned to two groups,the Western medicated group（WMG）and the Chinese herbs group（CHG）.The content of CD62P in all patients was detected by ELISA before and after hemodialysis.ResultsThe levels of blood urea nitrogen,creatinine,potassium,hematocrit,platelet count and carbon dioxide combining power（CO₂CP）as well as the expression of CD62P after treatment were significantly changed in both groups with significant difference as compared with those before treatment（both P<0.05）.And comparison between the two groups in expression of CD62P after treatment also showed significant difference（P<0.05）.But the improvement in TCM syndrome between the two groups was insignificantly different（P>0.05）.ConclusionHemodialysis with dialysate containing Chinese herbs of replenishing qi and activating blood circulation can decrease the expression of platelet membranous glycoprotein CD62P,which may be associated with the mechanism of Chinese herbs in treating CRF.

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