复方海蛇胶囊与盐酸多奈哌齐联合治疗阿尔茨海默病的临床研究

作者	单位
周智林	浙江省杭州市第三人民医院神经内科杭州310009
梁丽贞	浙江省杭州市第三人民医院神经内科杭州310009
严永兴	浙江省杭州市第三人民医院神经内科杭州310009

摘要点击次数: 1607

全文下载次数: 5

中文摘要:

目的研究复方海蛇胶囊(reinhartdt and sea cucumber capsule,RSC)与盐酸多奈哌齐联合治疗阿尔茨海默病(Alzhei mer’s disease,AD)的临床疗效、安全性及其对AD患者甲状腺功能轴的影响。方法68例患者随机分为RSC治疗组(23例,采用RSC口服)、盐酸多奈哌齐治疗组(21例,采用盐酸多奈哌齐口服)、联合治疗组(24例,采用RSC加盐酸多奈哌齐口服),治疗3、6个月,以MMSE、ADAS-Cog和ADL分数评定疗效;每组患者分别在治疗前,治疗3、6个月用放免法测定甲状腺素水平(TSH,FT3,FT4,TT3,TT4)。结果3组在治疗3、6个月,MMSE评分升高,ADAS-Cog、ADL评分降低,与治疗前比较差异有显著性(P<0.05,P<0.01)。联合治疗组治疗后(3、6个月)MMSE、ADAS-Cog、ADL评分与RSC组、盐酸多奈哌齐组比较,差异均有显著性(P<0.01)。治疗6个月联合治疗组FT3、FT4水平与治疗前比较差异有显著性(P<0.01)。盐酸多奈哌齐组、RSC组FT3、FT4、TSH、TT3、TT4水平治疗6个月后与治疗前比较差异无显著性(P>0.05)。3组患者未发现明显不良反应。结论RSC与盐酸多奈哌齐联合治疗AD安全、有效,无明显不良反应,作用优于单一药物组,其可能是通过影响AD患者甲状腺激素代谢,调节甲状腺激素水平从而进一步改善认知功能。

英文摘要:

ObjectiveTo study the efficacy and safety of Reinhartdt and sea cucumber capsule（RSC）combined with donepezil in treating Alzheimer’s disease（AD）,and its effect on thyroid function axis.Methods Sixty-eight patients were randomly assigned to the RSC group,the Donepezil group and the combined treatment group,who were treated for 3 and 6 months with RSC,Donepezil and RSC combined with Donepezil,respectively.The curative effect was evaluated by scoring according to Mini-Mental State Examination（MMSE）,ADAS-Cog and ADL chart,and the level of thyroid hormones,including TSH,FT₃,FT₄,TT₃ and TT₄,were measured with radioimmunoassay before treatment,3 and 6 months after treatment respectively.Results As compared with the baseline,MMSE score increased,ADAS-Cog score and ADL score decreased significantly in all the three groups after 3 months and 6 months of treatment（P<0.05 and P<0.01）,but the improvement in the combined treatment group was more significant than that in the other two groups（P<0.01）.After 6 months of treatment,the levels of FT₃ and FT₄ in the combined treatment group were significantly changed（P<0.01）,but no significant change in all the thyroid hormones was found in the other two groups.No obvious adverse reaction occurred in all the three groups.ConclusionRSC combined with Donepezil in treating AD is effective and safe with no evident adverse reaction,better than single drug treatment,which may be through influencing the metabolism of thyroid hormones to improve the cognition function of AD patients.

关闭