中药与舒乐安定治疗高血压病患者睡眠障碍的比较研究

作者	单位
李海聪	中日友好医院中医老年病科
杨毅玲	北京中医药大学诊断教研室
马明	中日友好医院中医老年病科
李求兵	中日友好医院中医老年病科
杨学青	中日友好医院中医老年病科
王燕	中日友好医院中医老年病科
陈钢	中日友好医院中医老年病科
田心	中日友好医院中医老年病科
陈晓光	中日友好医院中医老年病科
张铁忠	中日友好医院中医老年病科

摘要点击次数: 1542

全文下载次数: 3

中文摘要:

目的观察中医药治疗高血压病患者睡眠障碍的临床疗效及睡眠改善后患者血压的变化。方法高血压同时有睡眠障碍患者239例随机分为中医治疗组(123例)和对照组(116例),分别采用中医辨证论治与西药舒乐安定治疗14天,并观察睡眠障碍量表(SDRS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、药物不良反应及患者血压的变化。结果中医药对患者入睡困难的疗效明显,对早段失眠症状的减分亦比较明显,并能改善睡眠质量,延长睡眠时间,达到患者的生理睡眠要求,其有效率为80.5%(99/123例),总体疗效优于舒乐安定组〔66.4%(77/116例),P<0.05〕;同时随着睡眠的改善,治疗组患者的血压(DBP和SBP)较对照组明显下降(P<0.001),目标血压(<140/90mmHg)的达标率〔53.7%(66/123例)〕也显著高于对照组〔39.7%(46/116例),P<0.05〕。不良反应治疗组也明显少于对照组。结论中医药治疗高血压病患者睡眠障碍有显著疗效,且其疗效优于舒乐安定。同时改善患者睡眠有利于改善患者的血压状态。

英文摘要:

ObjectiveTo study the efficacy of traditional Chinese medicine(TCM)in treating somnipathy in patients with hypertension,and to observe the change of blood pressure after sleep being improved.MethodsTwo hundred and thirty-nine patients with hypertension accompanied somnipathy were randomly assigned to two groups,123 patients in the treated group were treated with TCM according to syndrome differentiation,and 116 in the control group treated with Estazolam.Changes of blood pressure,scores of sleep dysfunction rating scale(SDRS),Hamilton anxiety rating scale(HAMA)and treatment emergent symptom scale(TESS)before and after treatment were observed.ResultsTCM showed a significant effect on hypnagogic disturbance,and significantly reduced the scores of insomnia syndromes in early sleep stage,improve the quality of sleep,prolong the sleeping time to fulfill the physiological requirement,the total effective rate being 80.5%(99/123 cases),with the overall effect higher than that(66.4%,77/116 cases)in the control group(P<0.05).Along with the improving of sleep,blood pressure,both systolic and diastolic,reduced in both groups,but with the reduction in the treated group superior to that in the control group(P<0.01),and the rate of reaching target BP(<140/90 mmHg)in the former was also significantly higher than that in the latter(39.7%,46/116 cases,P<0.05).As compared with those in the control group,the occurence of adverse reaction,were less in the treated group(P<0.05).ConclusionTCM has better efficacy in treating somnipathy of hypertension patients than Estazolam.And the improvement of somnipathy is favorable for improving the hypertensive condition of patient.

关闭