鸦胆子油乳剂对非小细胞肺癌患者细胞免疫功能及生活质量的影响

作者	单位
田华琴	广东省佛山市中医院肿瘤科广东528000
余寿益	广东省佛山市中医院肿瘤科广东528000
王斌	广东省佛山市中医院肿瘤科广东528000
梁贵文	广东省佛山市中医院肿瘤科广东528000
黄小青	广东省佛山市中医院肿瘤科广东528000

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中文摘要:

目的观察鸦胆子油乳剂对经化疗治疗非小细胞肺癌患者的免疫功能及生活质量的影响。方法将115例中晚期(Ⅲ/Ⅳ期)非小细胞肺癌患者随机分为两组,对照组(57例)给予GP方案化疗,治疗组(58例)给予鸦胆子油乳剂联合GP方案化疗。治疗2个周期后进行疗效评价。结果治疗组与对照组的有效率分别为51.8%、47.4%,两组差异无统计学意义(P>0.05)。治疗后治疗组细胞免疫功能改善,生活质量提高(P<0.05,P<0.01),而对照组化疗后机体细胞免疫功能及生活质量较化疗前降低(P<0.05)。结论鸦胆子油乳剂联合化疗治疗中晚期非小细胞肺癌患者,可以提高患者的细胞免疫功能、改善患者的生活质量。

英文摘要:

ObjectiveTo observe the effect of Fructus Bruceae oil emulsion(FBE)on cellular immune function(CIF)and quality of life(QOF)in patients with non-small cell lung cancer(NSCLC)after chemotherapy.MethodsOne hundred and fifteen patients with mid-late stage NSCLC were randomly assigned to two groups,the 57 patients in the control group were only treated with chemotherapy of GP regimen,58 in the treatment group with the chemotherapy of the same regimen and combined with FBE.The clinical efficacy was evaluated after two cycles of chemotherapy.ResultsThe effective rate was 51.8% and 47.4% in the treatment group and the control group respectively,the difference between them was insignificant(P>0.05).CIF and QOF in the treatment group were better than those in the control group after chemotherapy respectively(P<0.01),in the latter,CIF and QOF were desreased after chemotherapy(P<0.05).ConclusionFBE combined with chemotherapy can improve the cellular immune function and quality of life in patients with mid-late stage NSCLC.

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