白芍总甙联合柳氮磺吡啶治疗强直性脊柱炎临床观察

作者	单位
王锁良	西安交通大学医学院第一附属医院康复中心
王俊鹏	陕西省妇幼保健院西安交通大学医学院第一附属医院康复中心
卞红	西安交通大学医学院第一附属医院康复中心
王辉	西安交通大学医学院第一附属医院康复中心
李鹏	西安交通大学医学院第一附属医院康复中心

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中文摘要:

目的评价白芍总甙联合柳氮磺吡啶治疗强直性脊柱炎的疗效和不良反应情况。方法67例患者随机分为两组,治疗组(34例)用白芍总甙加柳氮磺吡啶治疗,对照组(33例)用甲氨喋呤加柳氮磺吡啶治疗。观察治疗前后两组临床指标[包括腰背痛指数、晨僵时间、外周关节痛指数、扩胸度、Schober试验、Bath强直性脊柱炎病情活动性指数表(BASDAI)、Bath强直性脊柱炎功能指数表(BASFI)]、血沉、C反应蛋白、骶髂关节X线等情况。结果两组治疗后临床指标均比治疗前改善(P＜0．05);除腰背痛指数、外周关节痛指数两组比较差异有显著性(P＜0．05)外,其余指标两组比较差异均无显著性。治疗组发生不良反应较对照组少(P＜0．05)。结论白芍总甙联合柳氮黄吡啶治疗强直性脊柱炎有较好的临床效果,且不良反应少而轻。

英文摘要:

Objective To evaluate the efficacy and adverse reaction of total glucosides of paeony (TGP) combined with sulfasalazine (SSZ) in the treatment of ankylosing spondylitis (AS).Methods Sixty-seven AS patients were randomly assigned to 2 groups:the treatment group (34 cases) treated with TGP and SSZ,the control group (33 cases) with methotrexate (MTX) and SSZ.Changes of clinical efficacy related indexes includ- ing lumber pain index,morning stiffness time,peripheral joint pain index,thoracic expansion,Schober test, Bath AS disease active index (BASDAI),Bath AS functional index (BASFI),the levels of erythrocyte sedimen- tation (ESR) and C-reactive protein (CRP),and X-ray of sacroiliac joint were observed.Results The clinical efficacy indexes were significantly improved after treatment in the two groups (P＜0.05).Except that the im- provement of lumber pain index and peripheral joint pain index was better in the treatment group than that in the control group (P＜0.05),no significant difference was found in the other indexes between the two groups. The occurrence of adverse reation was less in the treatment group than in the control group (P＜0.05).Conclu- sion TGP treatment combined with SSZ shows favorable effect on AS with less and milder adverse reaction.

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