| 张西波,崔乃强,李东华.清热利湿方防治兔胆色素结石形成的实验研究[J].中国中西医结合杂志,2007,(3):241-243 |
| 清热利湿方防治兔胆色素结石形成的实验研究 |
| Effect of Clearing Heat and Removing Dampness Method on Formation of Pigment Gallstones in Rabbits |
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| DOI： |
| 中文关键词: 清热利湿方 胆色素结石形成 胆红素 总胆汁酸 β-葡萄糖醛酸酶 |
| 英文关键词:clearing heat and removing dampness Recipe lithogenesis of pigment gallstones bilirubin total bile acid β-glucuronidase |
| 基金项目:天津市科委资助项目(No．033607011) |
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| 中文摘要: |
| 目的动态观察清热利湿方对兔胆色素结石模型胆汁成分的影响。方法取健康家兔40只,随机分为对照组,细菌感染组,清热利湿中药大、小剂量组;造成胆色素结石模型,观察胆汁中总胆红素（TB）、游离胆红素（UCB）、总胆汁酸（TBA）、钙离子(Ca2+)、细菌性和内源性β-葡萄糖醛酸酶（β-Gase）活性的变化。结果清热利湿中药能明显降低胆汁中TB、UCB、Ca2+含量（P＜0．05）,增加胆汁中总胆汁酸含量（P＜0．05）,并能降低胆汁中细菌性和内源性β-Gase活性（P＜0．05）。结论清热利湿方具有很好的降低胆汁成石性的作用。 |
| 英文摘要: |
| Objective To observe dynamically the effect of drugs for clearing heat and removing dampness （CHRD） on biliary components in rabbits with pigment gallstones （PGS）.Methods Forty rabbits were estab- lished into PGS model and randomly divided into 3 groups,the bacterial infection group,the CHRD low-dose group and the CHRD high-dose group.Besides,a normal group was set up with healthy rabbits for control. Changes of total bilirubin （TB）,unconjugated bilirubin （UCB）,total bile acid （TBA）,Ca2+,bacterial and en- dogenousβ-glucuronidase （β-Gase） in bile were observed.Results CHRD drugs significantly decreased the con- tents of UCB,Ca2+,bacterial and endogenousβ-Gase （P＜0.05）,and increased TBA in bile （P＜0.05）. Conclusion CHRD drugs have good effect in reducing the lithogenesis of the pigment gallstones. |
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