参灵益肝颗粒抗乙型肝炎病毒作用的实验研究

作者	单位
张洪泉	扬州大学医药研究所
葛慧	扬州大学医药研究所
李心	扬州大学医药研究所
武玉清	扬州大学医药研究所
陈压西	重庆医科大学肝炎病研究所

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中文摘要:

目的研究参灵益肝颗粒体内抗乙型肝炎病毒的作用。方法采用重庆麻鸭乙型肝炎动物模型,随机分为参灵益肝颗粒(简称参灵益肝)1．6 g/kg、3．2 g/kg、6．4 g/kg 3个剂量组,拉米夫定(阳性药)组及病毒对照组。检测血清中的DHBV-DNA、DHBsAg的变化情况及观察肝脏病理改变情况。结果参灵益肝3个剂量组及阳性药组用药21天后血清中的DHBV-DNA显著降低(P＜0．05或P＜0．01),停药7天后阳性药组及参灵益肝小、大剂组出现反跳。参灵益肝3个剂量组血清中DHBsAg均无明显降低。镜下观察各组鸭肝脏的病理改变较轻,参灵益肝3个剂量组与阳性药组差异无显著性(P＞0．05)。结论参灵益肝颗粒在鸭体内有一定的抑制鸭乙型肝炎病毒DNA的作用。

英文摘要:

Objective To study the viral inhibitory effect of Shenling Yigan Granule (SYG) on duck hep- atitis B virus (DHBV) in vivo.Methods Chongqing ducks infected with DHBV were used.They were ran- domly divided into five groups,the small-,medium- and high- dose (1.6 g/kg,3.2 g/kg,6.4 g g/kg) SYG groups,the lamivudine positive control group,and the model group.The changes of serum DHBV-DNA,DHB- sag contents and hepatic pathology were observed.Results The serum content of DHBV-DNA in the three SYG groups and the positive control group was significantly decreased (P＜0.05),while it was rebounded in the latter at day 7 after stopped lamivudine administration.The change of DHBsAg level was insignificantly in all groups.And the hepatic pathological change in the SYG groups and positive control group was slighter than that in the model control group,but showed insignificant difference in comparison between the SYG groups and the model group (P＞0.05).Conclusion SYG has certain in vivo inhibitory effects on DHBV-DNA.

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