一贯煎对非小细胞肺癌NP方案化疗减毒作用的临床研究

作者	单位
张霆	武警浙江省总队杭州医院
马胜林	浙江省肿瘤医院
岳建华	武警浙江省总队杭州医院
贾英杰	天津中医药大学第一附属医院
张艳	武警浙江省总队杭州医院
谢广茹	天津医科大学附属肿瘤医院
徐粟	浙江大学医学院附属第二医院

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中文摘要:

目的观察一贯煎对非小细胞肺癌患者NP方案化疗减毒作用。方法92例非小细胞肺癌患者随机分为NP方案化疗组(简称对照组),NP方案化疗加一贯煎组(简称治疗组)各46例。以肝肾功能、T细胞亚群、NK细胞、KPS评分、欧洲癌症研究与治疗协会(EORTC)QLQ-C30生活质量调查问卷、EORTC LC13肺癌特异量表为指标进行疗效观察。结果治疗42天后治疗组肝肾功能、T细胞亚群、NK细胞、KPS记分、QLQ-C30生活质量评分、LC13肺癌特异量表评分均优于对照组(P<0·05)。结论一贯煎可减轻非小细胞肺癌患者NP方案化疗所致毒副反应,改善生活质量。

英文摘要:

Objective To observe the toxicity-attenuation effect of Yiguan Decoction(YGD) in treatment of non-small cell lung cancer(NSCLC) with NP protocol of chemotherapy.Methods Ninety-two NSCLC patients were randomly assigned to two groups equally,the control group given only NP protocol of chemotherapy and the treated group given the same protocol of chemotherapy plus YGD.Hepatic function,T-cell subgroup and NK cell were examined,and quality of life(QOL) was evaluated with scoring by Karnofsky performance status(KPS),Quality of Life Questionnaire-Core30(EORTC QLQ-C30) and Special Scale for lung cancer(EORTC LC13) issued by European Organization for Research and Treatment of Cancer.Results The effects on all the above-mentioned indexes in the treated group were better than those in the control group after 42 days of treatment(P<0.05).Conclusion YGD could not only reduce the side and toxic effects caused by NP protocol of chemotherapy in NSCLC patients but also improve their QOL.

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