固本抑瘤Ⅱ号配合化学药物动脉灌注治疗晚期胰腺癌的临床观察

作者	单位
张青	首都医科大学附属北京中医医院肿瘤科北京100010
王笑民	首都医科大学附属北京中医医院肿瘤科北京100010
迟惠昌	首都医科大学附属北京中医医院肿瘤科北京100010
杨国旺	首都医科大学附属北京中医医院肿瘤科北京100010
赵文硕	首都医科大学附属北京中医医院肿瘤科北京100010
胡凤山	首都医科大学附属北京中医医院肿瘤科北京100010

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中文摘要:

目的观察固本抑瘤Ⅱ号配合化学药物动脉灌注治疗晚期胰腺癌的疗效。方法65例晚期胰腺癌患者,随机分为治疗组(固本抑瘤Ⅱ号配合化学药物动脉灌注)35例、对照组(化学药物动脉灌注)30例。结果经2个月治疗,治疗组与对照组临床有效率分别为17·1%、13·3%,两组比较差异无显著性;临床获益率分别为54·2%、40·0%,两组比较差异有显著性(P<0·05);对晚期胰腺癌的疼痛有效率分别为64·5%、59·2%,组间差异无显著性。治疗组血液高凝状态降低,患者的细胞免疫功能提高,化疗药物的毒副反应缓解,患者的生活质量明显改善。结论固本抑瘤Ⅱ号有明显的减毒增效作用,其配合化学药物动脉灌注治疗晚期胰腺癌有较好的疗效。

英文摘要:

Objective To observe the effects of Guben Yiliu Ⅱ(GYⅡ) combined with arterial perfusion with chemotherapeutic agent on advanced pancreatic cancer(APC).Methods Sixty-five APC patients were randomly assigned to the treated group(35 cases) given GY Ⅱ and arterial perfusion with chemotherapeutic agent and the control group(30 cases) with chemotherapeutic agent alone.Results The clinical beneficial rate was 54.2% in the treated group and 40.0% in the control group,with significant difference between them(P<0.05),the overall effective rate being 17.1% and 13.3%,and the effective rate in relieving pain being 64.5% and 59.2% in the treated and the control group respectively,all showed insignificant difference between groups(P>0.05).Furthermore,in the treated group after treatment,the blood hypercoagulation state ameliorated,cellular immunity elevated,the toxic and side-effects of chemical medicine relieved,and the quality of life improved.Conclusion GY Ⅱ is effective in enhancing clinical effects and relieving toxic and side-effects of chemotherapy,and so,better efficacy could be obtained by therapy of GY Ⅱ and arterial perfusion with chemotherapeutic agent for treatment of APC.

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