扶正解毒颗粒治疗长期接触镍的冠心病患者的临床观察

目的研究中药扶正解毒颗粒对长期接触镍的冠心病患者的临床疗效及其对心电图和心肌酶的影响。方法将60例患者随机分为两组:治疗组30例采用中药扶正解毒颗粒及西药治疗;对照组30例仅用西药治疗,疗程均为4周。同期设立健康对照组15名,为同地区非接触镍健康人群。观察两组治疗前后临床症状、心电图的变化,检测血清心肌酶肌酸激酶(CK)、乳酸(LD)、乳酸脱氢酶(LDH)、红细胞膜钠钾三磷酸腺苷酶(Na+-K+-ATPase)、钙三磷酸腺苷酶(Ca2+-ATPase)的变化及血清镍含量。结果治疗组中医症状和心电图均改善,疗效明显优于对照组(P<0·05)。两组患者治疗前血清CK、LD、LDH、镍水平均明显高于健康对照组,血清Na+-K+-ATPase、Ca2+-ATPase水平均明显低于健康对照组;治疗后,治疗组血清CK、LD、LDH、镍水平均明显下降,且下降幅度较对照组明显(P<0·05或P<0·01);血清Na+-K+-AT-Pase、Ca2+-ATPase水平均上升,且较对照组有显著性差异(P<0·05或P<0·01)。结论扶正解毒颗粒可降低血清镍含量,恢复心肌酶的活性,从而改善患者临床症状及心电图的异常。

英文摘要:

Objective To study the clinical efficacy of Fuzheng Jiedu Granule(FJG) in coronary heart disease(CHD) patients in long term contact with nickel(Ni) and its effect on electrocardiogram(ECG) and cardial enzymes.Methods Sixty cases were randomly assigned to two groups with 30 cases in each group,the treatment group treated with FJG plus Western medicine and the control group given Western medicine alone.The therapeutic course in both groups was 4 weeks.Another 15 healthy subjects from the same region were taken as the healthy control.Changes of clinical symptoms and ECG were observed,and the serum levels of creatine kinase(CK),lactic acid(LD),lactic dehydrogenase(LDH),Na+-K+-ATPase,Ca2+-ATPase and Ni were detected before and after treatment.Results The ameliorative effects on symptoms,signs and ECG in the treatment group were superior to those in the control group(P<0.05).Compared with healthy subjects,the serum levels of CK,LD,LDH and Ni were higher and the serum levels of Na+-K+-ATPase and Ca2+-ATPase were lower in patients before treatment;after treatment,the decrease of serum CK,LD,LDH and Ni levels and increase of serum Na+-K+-ATPase and Ca2+-ATPase were more significant in the treatment group than those in the control group(P<0.05 or P<0.01).Conclusion FJG can decrease the serum Ni level,recover the activity of myocardial enzymes,thus to improve symptoms and abnormal ECG figures in CHD patients.

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