辨证治疗鼻咽癌急性放射反应的临床观察

Clinical Observation on TCM Treatment According to Syndrome Differentiation in Relieving Acute Radio-reaction in Nasopharyngeal Carcinoma Patients

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中文关键词: 鼻咽癌放射治疗急性放射反应中医辨证治疗

英文关键词:nasopharyngeal carcinoma radiotherapy acute radio-reaction traditional Chinese medicine treatment according to syndrome differentiation

基金项目:

作者	单位
宋培荣	天津市南开医院耳鼻喉科
邱宝珊	广州中医药大学第一附属医院耳鼻喉科
吴延涛	广州中医药大学第一附属医院耳鼻喉科
钟艳平	广州中医药大学第一附属医院耳鼻喉科

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中文摘要:

目的观察中医药辨证治疗对鼻咽癌急性放射反应的影响。方法将195例确诊为鼻咽癌并首次放疗的患者,分为对照组89例(单纯放疗7周),治疗组106例(在放疗同时给予中药治疗至放疗后5周)。比较两组急性放射反应的总体变化、各系统及各周放射反应的变化。结果治疗组急性放射反应总积分,皮肤、口咽黏膜、唾液腺、喉、耳、上消化道、中枢神经系统的急性放射反应积分均较对照组低(均P<0·05)。两组患者发生的急性放射反应在放疗1～7周呈上升趋势,8～10周逐渐减轻。结论在不影响放射治疗疗效的前提下,通过中医药辨证治疗可减轻鼻咽癌患者急性放疗反应。

英文摘要:

Objective To observe the effect of traditional Chinese medicine(TCM) treatment according to syndrome differentiation on acute radio-reaction(ARR) in nasopharyngeal carcinoma(NPC) patients.Methods One hundred and ninety-five NPC patients who received radiotherapy(RT) for the first time were randomly assigned to two groups:the control group(89 cases) was treated by RT alone for 7 weeks and the treatment group(106 cases) was treated by RT combined with oral taking TCM from starting of RT till 5 weeks after RT.The overall changes in total ARR score and ARR in different locations were observed weekly and compared.Results The total ARR score in the treatment group was significantly lower than that in the control group(P<0.05).And the ARR scores of different organs,including skin,oropharyngeal mucosa,salivary glands,larynx,ear,upper digestive tract,and central nervous system,in the treatment group were all lower than those of the corresponding organs in the control group.In addition,the ARR scores in both groups showed an ascending trend in the first 7 weeks and a descending trend from the 8th to the 10th week after beginning RT.Conclusion TCM treatment could relieve the ARR in the NPC patients without any affection on the efficacy of RT.

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