清热理气冲剂对功能性消化不良患者临床疗效、胃电图及胃排空的影响

目的评价清热理气冲剂对功能性消化不良(functional dyspepsia,FD)患者的临床疗效、胃电活动和胃排空的影响。方法对32例动力障碍型FD患者腹胀、腹痛、早饱、嗳气、反胃、恶心、呕吐、食欲不振8种症状进行治疗前后症状评分,给予清热理气冲剂口服6天,治疗前后检测空腹胃电图与SPECT核素胃排空。结果除呕吐外其他7种症状评分和总症状积分治疗后显著降低(P<0.05);胃动过缓和胃动过速百分数均有显著降低(P<0.01);胃正常慢波、主功率及主频均有显著升高(P<0.01,P<0.05,P<0.05);75min以后各时相胃排空率较治疗前均有显著升高(P<0.05);胃半排空时间显著缩短(P<0.01);总症状积分改善与胃半排空时间改善呈显著直线正相关(r=0.8929,P<0.01)。结论清热理气冲剂通过调节胃电节律和功率,增加胃动力,提高胃排空功能,从而改善了FD患者的症状。

英文摘要:

Objective To evaluate the effects of Qingre Liqi Granule (QLG) on clinical therapeutic efficacy, electrogastrogram (EGG) and gastric emptying in patients with functional dyspepsia (FD). MethodsThirty-two FD patients of dyskinesis type enrolled were treated with QLG by oral taking for 6 days. Scoring on 8 kinds of symptoms, including abdominal distension, abdominal pain,morning gastric fullness, belching, regurgitation, nausea, vomiting, and anorexia, fasting EGG and the gastric emptying determination were performed using single photon emission computed tomography (SPECT) before and after treatment. ResultsThe total and individual scores of clinical symptoms, expect that of vomiting, significantly decreased after treatment (P<0.05), and the percentage of patients with tachygastria and bradygastria significantly decreased (P<0.01) at the same time. EGG after treatment showed significantly elevated rates of normal slow wave dominant power, and nearly normalized dominant frequency. An increased gastric emptying rate at different phases after 75 min (P<0.05), and significantly shortened gastric emptying half-time (P<0.01) were shown meanwhile in gastric emptying detection. The improvement of symptom score and gastric emptying half-time showed significant positive linear correlation (r=0.8929, P<0.01). ConclusionQLG can improve symptoms of FD patients by regulating the rhythm and power of gastric electro-wave, increasing gastric motility and enhancing gastric emptying function.

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