加味逍遥丸联合阿米替林治疗抑郁症疗效和依从性比较

作者	单位
杨占宇	辽宁省朝阳市康宁医院
张文宝	辽宁省朝阳市中心医院
刘建林	辽宁省朝阳市康宁医院
陈兴	辽宁省朝阳市康宁医院

摘要点击次数: 1922

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中文摘要:

目的比较观察加味逍遥丸联合阿米替林与盐酸氟西汀治疗抑郁症的疗效、不良反应及依从性。方法将符合CCMD-3抑郁发作诊断标准的64例患者随机分为两组,分别用加味逍遥丸联合阿米替林(中西药组,32例)和百优解(西药组,32例)治疗,于用药前及用药后2、4、12周时用汉密尔顿(HAMD)评定疗效,记录不良反应。从12周起定时随访至24周,比较两组疗效及依从性。结果两组患者于治疗第2周时HAMD评分下降,西药组优于中西药组(P<0.05),第4周起两组临床疗效和评分差异均无显著性。12周至24周随访发现,中西药组复发3例,西药组因过早停药而复发14例。结论加味逍遥丸联合阿米替林治疗抑郁症疗效与盐酸氟西汀相当,不良反应少,价格低廉。

英文摘要:

Objective To comparatively observe the curative effect,adverse reaction and compliance of modified Xiaoyao Pill combining amitriptyline(MXP-At)in treating patients with depression.Methods Sixty-four patients with diagnosis of depression matched to the Chinese Classification of Mental Disorders(CCMD-3)were randomly assigned to 2 groups,the treatment group treated with MXP-At and the control group with fluoxeline,32 cases in each group.The curative effect was evaluated by Hamilton depression(HAMD)scale and the adverse reaction was recorded before treatment and at the 2nd,4th and 12th week of the treatment.Patients were regularly followed up from the 12th week to the 24 th week.The curative effect and compliance in the two groups were compared.Results The HAMD score dropped in both groups from the 2nd week of the treatment,and at that time,it was lower in the control group than that in the treatment group(P<0.05);but at the 4th week,no significant difference was found in the therapeutic effect and the HAMD score between the two groups.However,3 and 14 cases in the treatment and the control group were relapsed during the 12 weeks of follow-up respectively.Conclusion MXP-At shows a curative effect similar to fluoxetine on depression but with less adverse reaction,and is not expensive.

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