| 王学习,赵健雄,程卫东,陈茹,白德成.糙叶败酱大孔吸附树脂提取物对荷瘤小鼠红细胞免疫功能的影响[J].中国中西医结合杂志,2007,(8):732-735 |
| 糙叶败酱大孔吸附树脂提取物对荷瘤小鼠红细胞免疫功能的影响 |
| Effects of Patrinia scabra Bunge Macroporous Adsorptive Resins Extracts on Erythrocyte Immune Function in Tumor Bearing Mice |
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| DOI： |
| 中文关键词: 糙叶败酱 大孔吸附树脂 红细胞免疫 CD35 CD44s |
| 英文关键词:Patrinia scabra Bunge macroporous adsorptive resins erythrocyte immune function CD35 CD44s |
| 基金项目:国家中药管理局课题(No.04-05ZP61);甘肃省科技攻关项目(No.2GS042-A43-014-15) |
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| 中文摘要: |
| 目的观察糙叶败酱大孔吸附树脂提取物对荷瘤小鼠红细胞免疫功能的调节作用。方法D101大孔吸附树脂分离糙叶败酱水提物,测定其多糖含量和皂甙含量;糙叶败酱提取物作用于荷瘤小鼠(S180),观察生命延长率,检测红细胞C3b受体花环率、红细胞免疫复合物花环率、红细胞肿瘤细胞花环率和红细胞膜CD35和CD44s数量。结果糙叶败酱大孔吸附树脂提取物中多糖含量为21.4%,皂甙含量为41.8%,作用于荷瘤小鼠,生命延长率增加,红细胞C3b受体花环率和红细胞肿瘤细胞花环率升高,红细胞免疫复合物花环率降低,红细胞天然免疫活性得到改善,同时红细胞膜CD35和CD44s数量增加,与模型组比较,差异有显著性(P<0.05或P<0.01)。结论糙叶败酱大孔吸附树脂提取物有一定的红细胞免疫调节作用。 |
| 英文摘要: |
| Objective To study the erythrocyte immuno-regulatory effect of Patrinia scabra Bunge extracts extracted by macroporous adsorptive resins in tumor bearing mice. Methods Patrinia scabra Bunge was extracted by macroporous adsorptive resins, and the amount of polysaccharides and saponins in the extract were determined. Mice bearing S180 tumor were treated with the extract and their survival prolongation rate, erythrocyte rosette formation rates of C3b receptor (ERR-CR), immune complex (ERR-IC) and tumor cell (ERR-TC), as well as the CD35 and CD44s were observed. Results Polysaccharide content was 21.4%, saponin 41.8% in the extract. As compared with the model group, the survival rate was increased, the erythrocyte immune function was improved (showed increase of ERR-CR and ERR-TC, decrease of ERR-IC), and the amount of CD35 and CD44s in red blood cell membrane increased in mice after being treated with the extract (P<0.05 or P<0.01). Conclusion Extract of Patrinia scabra Bunge extracted by macroporous adsorptive resins can regulate the erythrocyte immune function to a certain extent. |
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