| 赵虹,李文伟,高俊鹏,周子懿,吕磊,汪涛,顾喜喜,范越,陆振宇,唐宇平,周洋,蔡定芳.补肾养肝方药治疗肝肾阴虚型帕金森病临床研究[J].中国中西医结合杂志,2007,(9):780-784 |
| 补肾养肝方药治疗肝肾阴虚型帕金森病临床研究 |
| Clinical Trial on Treatment of Parkinson’s Disease of Gan-Shen Yin Deficiency Type by Recipe for Nourishing Gan-Shen |
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| DOI： |
| 中文关键词: 帕金森病 补肾养肝方药 帕金森病统一评分量表 Hoehn&Yahr评级 左旋多巴剂量 |
| 英文关键词:Parkinson’s disease recipe for nourishing Gan-Shen unified Parkinson’s disease rating scale Hoehn & Yahr grading levodopa dose |
| 基金项目:国家十一五科技攻关项目(No.2006BAI04A11);上海市医学领军人才项目(No.BR97016);卫生部科学研究基金(No.98-2-151);国家中医药管理局科研基金(No.97A201-7/04-05JP23);教育部博士点专项科研基金(No.9747);上海市卫生局基金(No.2004L004C) |
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| 中文摘要: |
| 目的观察补肾养肝方药治疗肝肾阴虚型帕金森病临床疗效。方法将121例帕金森病患者采用区组随机化方法,按照1∶1比例分为对照组与治疗组。对照组根据"国际帕金森病治疗指南"用药原则进行治疗,治疗组在此基础上予以补肾养肝方药,连续服用12个月,试验终点时间为第12个月。在治疗前、入组后每间隔3个月及试验终点时间分别进行帕金森病统一评分量表(UPDRS)、中医主要与次要症状的评分,治疗前与试验终点时间分别进行左旋多巴平均每日用量和Hoehn&Yahr评级比较。结果治疗后两组患者UPDRS评分均呈上升趋势,治疗组较对照组UPDRS评分上升明显减慢,在治疗后第9、12个月时,两组UPDRS评分比较差异有显著性(P<0.05),并且治疗组中医症状评分明显低于对照组(P<0.05)。试验终点时治疗组患者平均每日左旋多巴用药量明显低于对照组(P<0.05),但两组Hoehn&Yahr评级差异无显著性(P>0.05)。结论补肾养肝方药可以减慢肝肾阴虚型帕金森病患者UPDRS评分的上升速度,改善肝肾阴虚症状,同时减少每日左旋多巴用量,有效治疗肝肾阴虚型帕金森病。 |
| 英文摘要: |
| Objective To observe the curative effect of the recipe for nourishing Gan-Shen on Parkinson’s disease (PD) of Gan-Shen yin deficiency type. Methods One hundred and twenty-one PD patients were randomly assigned by blocking design to the control group and the treated group in the ratio of 1∶1. All were treated according to the international medication guiding principle for PD treatment, but the treated group was administered with the recipe for nourishing Gan-Shen additionally. The treatment course lasted for 12 consecutive months, and the end point was the end of the 12th month. The unified Parkinson’s disease rating scale (UPDRS) score, TCM primary and secondary symptom scores were evaluated before treatment, every 3 months of treatment and at the end point. The average daily levodopa dose and the Hoehn & Yahr grading were assessed before treatment and at the end point. Results After treatment, UPDRS score in both groups showed an ascending trend at a slower rate in the treated groups than in the control group. At the 9th and 12th month of medication, a significant difference was found in UPDRS score between the two groups (P<0.05), and the TCM symptom score was obviously lower in the treated group than in the control group (P<0.05). At the end point of the trial, the average daily levodopa dose used was lower in the treated group than in the control group (P<0.05) and there was no significant difference in the Hoehn & Yahr score between the two groups (P>0.05). Conclusion The recipe for norishing Gan-Shen can slow the ascending trend of UPDRS score in the PD patients, improve the symptoms of Gan-Shen yin deficiency, and decrease the daily levodopa dose used, showing a curative effect on PD of Gan-Shen yin deficiency type. |
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