盆腔炎颗粒对血瘀兼肾虚型慢性盆腔炎患者免疫学指标的影响

Effect of Penqiangyan Granule on the Immune Function of Patients with Chronic Pelvic Inflammatory Disease of Blood-stasis and Shen-deficiency Syndrome Type

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中文关键词: 盆腔炎颗粒慢性盆腔炎免疫功能

英文关键词:Penqiangyan Granule chronic pelvic inflammatory disease immune function

基金项目:山东省中医药管理局资助课题(No.2001-02)

作者	单位
刘瑞芬	山东中医药大学附属医院
杨晓娜	山东中医药大学

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中文摘要:

目的探讨盆腔炎颗粒对血瘀兼肾虚型慢性盆腔炎患者免疫学指标的影响。方法将60例血瘀兼肾虚型慢性盆腔炎患者随机分为治疗组(30例,服用盆腔炎颗粒)、对照组(30例,服用盆炎净颗粒),疗程均为4周。观察两组患者临床疗效和治疗前后外周血T细胞亚群水平、血清肿瘤坏死因子-α(TNF-α)以及白细胞介素-2(IL-2)浓度的变化。结果治疗组和对照组总有效率分别为96.7%和63.3%,两组比较差异有显著性(P<0.05)。治疗组治疗后外周血CD4、CD4/CD8、血清IL-2较治疗前上升,CD8和血清TNF-α较治疗前下降(均P<0.05),上述指标与对照组治疗后比较差异亦均有显著性(P<0.05)。结论盆腔炎颗粒可提高血瘀兼肾虚型慢性盆腔炎患者免疫功能,减轻炎症。

英文摘要:

Objective To explore the effect of Penqiangyan Granule (PG) on the immunity of patients with chronic pelvic inflammatory disease (CPID) of blood stasis and Shen-deficiency syndrome (BSSDS) type. Methods Sixty patients were randomly assigned to two groups: the treatment group treated with PG and the control group with Penyanjing Granule, 30 cases in each group. The treatment course was 4 weeks for both groups. The clinical efficacy, plasma levels of CD4 and CD8, and the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-2 (IL-2) were measured before and after treatment. Results After treatment, the total effective rate in the treatment group and the control group was 96.7% and 63.3% respectively with significant difference between groups (P<0.05); in the treatment group the plasma CD4, CD4/CD8 and serum IL-2 increased obviously, while the plasma CD8 and serum TNF-α decreased markedly (P<0.05), all were significantly different with those in the control group (P<0.05). Conclusion PG can improve the immune function and alleviate inflammation in CPID patients of BSSDS type.

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