调免化瘀汤治疗子宫内膜异位症临床观察

目的观察调免化瘀汤治疗子宫内膜异位症的疗效。方法治疗组用自拟调免化瘀汤治疗,对照组用安宫黄体酮治疗;同时检测两组治疗前后外周血T淋巴细胞亚群(CD3、CD4、CD8)及自然杀伤(NK)细胞。结果治疗组66例临床痊愈10例,显效22例,有效25例,无效9例,总有效率86.4%;对照组30例临床痊愈2例,显效6例,有效12例,无效10例,总有效率66.7%;两组比较,差异有显著性(P<0.05)。治疗组治疗前CD4及CD4/CD8比值均高于健康人组(P<0.01),CD8及NK细胞均低于健康人组(P<0.01);治疗后CD4与CD4/CD8比值显著下降(P<0.05),CD8与NK细胞显著回升(P<0.05),但均未恢复到正常水平。对照组治疗前后各项指标比较,差异均无显著性(P>0.05)。结论调免化瘀汤治疗子宫内膜异位症确切,并可调节患者免疫功能。

英文摘要:

Objective To investigate the clinical efficacy of Tiaomian Huayu Decoction (THD) in treating patients with endometriosis. Methods Patients in the treated group were administered with THD, those in the control group were given provera. T-cell sub-population including CD3, CD4, CD8 and CD4/CD8 ratio, and natural killer (NK) cell in peripheral blood in the two groups before and after treatment were determined. Results Among the 66 patients in the treated group, the treatment results was cured in 10, significantly effective in 22, effective in 25 and ineffective in 9, the total effective rate was 86.4%, while of the 30 in the control group, the corresponding number was 2, 6, 12, 10 and 66.7%, which was significantly different from that in the treated group respectively (P<0.05). The levels of CD4 and CD4/CD8 ratio were higher, CD8 and NK were lower in the treated group than those in the normal group before treatment (P<0.01), while these indexes were restored to some extent but still did not reach the normal level after treatment. All the above-mentioned indexes in the control group were insignificantly changed after treatment (P>0.05). Conclusion THD has definite effect in treating endometriosis, and it can also regulate the immune function of patients.

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