中药便乃通茶联合欧立康定防治化疗所致消化道反应疗效观察

作者	单位
李贵玲	华中科技大学同济医学院附属协和医院肿瘤中心
李亦武	华中科技大学同济医学院基础医学院武汉430022

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中文摘要:

目的观察中药便乃通茶联合欧立康定(Azasetron)对化疗所致消化道不良反应的防治效果。方法将64例接受泰素帝加顺铂方案(DP方案)化疗的恶性肿瘤患者,随机分为中药便乃通茶联合欧立康定治疗组和欧立康定对照组。治疗组化疗前一晚空腹服用中药便乃通茶剂1包,化疗前30min静脉推注欧立康定10mg,每天1次,连用2天;对照组化疗前静脉推注欧立康定10mg,每天1次,连用2天。观察两组的消化道反应(恶心、呕吐)及腹胀、便秘等不良反应的发生情况。结果两组预防化疗消化道反应总有效率相近〔87.5%(28/32例)和84.4%(27/32例)〕,两组比较,差异无显著性(P>0.05);但完全控制率分别为53.1%(17/32例)和43.8%(14/32例),两组比较差异有显著性(P<0.05)。治疗组与对照组便秘发生率分别为3.1%(1/32例)和59.4%(19/32例),腹胀发生率分别为15.6%(5/32例)和59.4%(19/32例),两组比较差异均有显著性(P<0.05)。结论应用欧立康定配伍中药便乃通茶,可以预防消化道反应,降低化疗所致便秘、腹胀纳差等不良反应,提高患者的依从性。

英文摘要:

Objective To observe the effects of Biannaitong medicinal tea (BNT) combined with Azasetron in preventing and treating the gastrointestinal reaction induced by chemotherapy. Methods Sixty-four patients underwent chemotherapy with DP regimen (docetaxol+DDP) were randomly assigned to two groups, the treated group and the control group. All patients were given 10 mg Azasetron intravenously 30 min before starting chemotherapy once a day for two successive days, but to patients in the treated group, 300 mL BNT was given orally additionally in the evenings before chemotherapy. The occurrence of adverse reactions, such as antiemetic efficacy constipation, abdominal distention, etc. was observed. Results The vomiting control rates in the two groups were insignificantly different (87.5% vs 84.4%, P>0.05), but difference in the complete control rates between them were significant (53.1 % vs 43.8 %, P<0.05). And the occurrences of constipation (3.1% vs 59.4%) and abdominal distention (15.6% vs 59.4%) in the two groups were also significantly different (both P<0.05). Conclusion BNT used in coordination with Azasetron for alleviating vomiting could enhance the antiemetic effect, reduce the adverse effects of chemotherapy, such as constipation, abdominal distension and anorexia, and thus to increase the compliance of patients.

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