手法针灸足三里穴脑内效应磁共振功能成像研究

作者	单位
肖叶玉	汕头大学医学院第二附属医院
杜丽	汕头大学医学院第二附属医院
洪璧楷	汕头大学医学院第二附属医院
陈小轲	汕头大学医学院第二附属医院
裴仁全	汕头大学医学院第一附属医院
吴仁华	汕头大学医学院第二附属医院

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中文摘要:

目的观察手法(补法)针灸足三里穴脑内效应的功能成像特点,探讨经络的本质和针灸治疗疾病的机理。方法选择26例健康志愿者,按双盲法随机分为穴位组(16例)与非穴位组(10例),使用GESigna1.5T超导MRI成像系统,采用Gradient echo-EPI序列进行功能成像,GE Signa工作站的Functool软件进行图像后处理,获得正相关系数(CC)脑功能图,统计学分析采用SPSS13.0软件。结果穴位组15例,13个脑功能区激活;非穴位组10例,10个脑功能区激活。其中穴位组颞叶激活区有特异性(精确概率法,P=0.022)。穴位组颞叶左右半球激活反应率差异有统计学意义(McNemer检验,P=0.020)。结论(1)针灸穴位在脑内有特定的功能区激活,穴位的治疗作用可能是通过脑作为中介治疗器官疾病和调治器官功能紊乱。(2)经络独特传感道的存在。

英文摘要:

Objective To observe the characteristic of the fMRI brain map in patients undergoing needling at Zusanli(ST36)by reinforcing method for exploring the essence of Meridian-Collaterals and the mechanisms of acupuncture in treating diseases.Methods Twenty-six healthy volunteers were randomly assigned to two groups by double blinded method,16 in the acupoint group and 10 in the non-acupoint group.Using GE Signa 1.5 T superconducting MRI system,the fMRI was performed with Gradient echo-EPI sequence.Post-processing of fMRI data was performed using the Functool software(GE-ADW4.0)to generate positive correlation coefficient brain functional activating images and the data was analyzed statistically using SPSS 13.0 software.Results Brain functional area was elicited in 13 out of the 15 patients in the acupoint group and 10 in the non-acupoint group.Among them,the temporal elicited area in the acupoint group showed specificity(Fisher’s Exact test,P=0.022)and only the difference in contralateral hemisphere activation rate was of statistical significance(McNemer test,P=0.020).Conclusion Acupoints has its own specific brain activated areas.The therapeutic effect of acupoint might be mediated through brain to treat diseases and regulate functional disorder of organs.There exists special transmission channel of meridian.

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